Fusion with stabilization for the treatment of post-operative Lumbar spondylodiscitis: Our experience

Volume 3 | Issue 2 | October 2022-March 2023 | page: 84-89 | Md. Anowarul Islam, Wayez Mahbub, Suvradev Saha, Afia Ibnat Islam

DOI: https://doi.org/10.13107/bbj.2022.v03i02.045


Authors: Md. Anowarul Islam [1], Wayez Mahbub [1], Suvradev Saha [1], Afia Ibnat Islam [2]

[1] Department of Spine Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
[2] Department of Spine Surgery, Holy Family & Red Crecent Medical College & Hospital, Dhaka, Bangladesh.

Address of Correspondence
Dr. Md. Anowarul Islam ,
Professor of Spine Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
E-mail: maislam.spine@gmail.com


Abstract


Objective: To analyse the outcome of fusion with stabilization for the treatment of postoperative lumbar spondylodiscitis.
Background: Post-operative spondylodiscitis is a dreadful complication following disc surgery. Treatment option is either conservative or operative, but till date, there are no universally accepted treatment protocol. Many studies suggest early surgical intervention provides good outcome. Different mode of surgical interventions can be applied for its treatment like debridement only, debridement followed by fusion with or without stabilization. In this study, we treat all of our patients having post-operative spondylodiscitis by fusion with stabilization.
Materials & methods: Retrospectively we reviewed 20 cases from January 2016 to July 2021 in Bangabandhu Sheikh Mujib Medical University and other private hospitals of Dhaka, Bangladesh. Post-operative spondylodiscitis was diagnosed according to history, specific clinical findings, laboratory and radiographic investigations. Surgery was the treatment of choice in our cases. Pre and postoperative evaluations were done by the Visual Analog scale (VAS), Nurick score for neurological outcome, Modified Kirkaldy–Willis criteria for functional outcome and Modified Lee’s criteria for fusion assessment.
Results: Total number of patients was 20. Mean age was 48 years (range 22-83). Average follow-up period was 12 months. The period between the surgery and the onset of symptoms was 14 to 28 days. Pre-operative VAS score was 8.10±1.7 and post-operatively was 1.7±0.6 at the last follow-up (P< 0.001). Pre & post-operative Nurick score was 2.7 & 0.7. Functional outcome was assessed in our study by Modified Kirkaldy-Willis criteria which shows 90% patient have satisfactory outcome while 10% have unsatisfactory outcome. Modified Lee’s criteria show definitive fusion in 55%, probable fusion in 35% & possible pseudarthrosis in 10% cases.
Conclusion: Early diagnosis and proper management are the keys to successful outcome of postoperative spondylodiscitis. Surgical management in the form of fusion and transpedicular fixation can give excellent results.
Keywords: Sondylodiscitis, Fusion, Stabilizationp


References


1) Guerado E, Cerván AM. Surgical treatment of spondylodiscitis. An update. International orthopaedics. 2012 Feb;36(2):413-20.
2) Basu S, Ghosh JD, Malik FH, Tikoo A. Postoperative discitis following single-level lumbar discectomy: Our experience of 17 cases. Indian Journal of Orthopaedics. 2012 Aug;46(4):427-33.
3) Jiménez-Mejías ME, de Dios Colmenero J, Sánchez-Lora FJ, Palomino-Nicás J, Reguera JM, García de la Heras J, García-Ordoñez MA, Pachón J. Postoperative spondylodiskitis: etiology, clinical findings, prognosis, and comparison with nonoperative pyogenic spondylodiskitis. Clinical Infectious Diseases. 1999 Jul 15;29(2):339-45.
4) Gerometta A, Bittan F, Rodriguez Olaverri JC. Postoperative spondilodiscitis. International orthopaedics. 2012 Feb;36(2):433-8.
5) Stošić-Opinćal TL, Perić V, Grujičić DM, Gavrilović S, Golubičić IV. The role of magnetic resonance imaging in the diagnosis of postoperative spondylodiscitis. Vojnosanitetski pregled. 2004;61(5):479-83.
6) Puranen J, Mäkelä J, Lähde S. Postoperative intervertebral discitis. Acta Orthopaedica Scandinavica. 1984 Jan 1;55(4):461-5.
7) WaNg X, Tao H, ZHu Y, Lu X, Hu X. Management of postoperative spondylodiscitis with and without internal fixation. Turk Neurosurg. 2015 Jan 1;25(4):513-8.
8) Osti OL, Fraser RD, Vernon-Roberts B. Discitis after discography. The role of prophylactic antibiotics. The Journal of Bone and Joint Surgery. British volume. 1990 Mar;72(2):271-4.
9) Tronnier V, Schneider R, Kunz U, Albert F, Oldenkott P. Postoperative spondylodiscitis: results of a prospective study about the aetiology of spondylodiscitis after operation for lumbar disc herniation. Acta neurochirurgica. 1992 Sep;117(3):149-52.
10) Ahmad M, Yasin M. LUMBER DISCITIS: PREVALENCE AND MANAGEMENT AFTER LUMBER DISC SURGERY. The Professional Medical Journal. 2010 Dec 10;17(04):628-32.
11) Lee JS, Moon KP, Kim SJ, Suh KT. Posterior lumbar interbody fusion and posterior instrumentation in the surgical management of lumbar tuberculous spondylitis. The Journal of Bone and Joint Surgery. British volume. 2007 Feb;89(2):210-4.
12) Moon MS, Kim SS, Lee BJ, Moon JL, Sihn JC, Moon SI. Pyogenic discitis following discectomy. Journal of Orthopaedic Surgery. 2012 Apr;20(1):11-7.
13) Blizzard DJ, Hills CP, Isaacs RE, Brown CR. Extreme lateral interbody fusion with posterior instrumentation for spondylodiscitis. Journal of Clinical Neuroscience. 2015 Nov 1;22(11):1758-61
14) Devkota P, Krishnakumar R, Kumar JR. Surgical management of pyogenic discitis of lumbar region. Asian Spine Journal. 2014 Apr;8(2):177.
15) Sapico FL, Montgomerie JZ. Pyogenic vertebral osteomyelitis: report of nine cases and review of the literature. Reviews of infectious diseases. 1979 Sep 1;1(5):754-76.
16) Santhanam R, Lakshmi K. A retrospective analysis of the management of postoperative discitis: a single institutional experience. Asian Spine Journal. 2015 Aug;9(4):559.
17) Jiménez-Mejías ME, de Dios Colmenero J, Sánchez-Lora FJ, Palomino-Nicás J, Reguera JM, García de la Heras J, García-Ordoñez MA, Pachón J. Postoperative spondylodiskitis: etiology, clinical findings, prognosis, and comparison with nonoperative pyogenic spondylodiskitis. Clinical Infectious Diseases. 1999 Jul 15;29(2):339-45.
18) Rohde V, Meyer B, Schaller C, Hassler WE. Spondylodiscitis after lumbar discectomy: incidence and a proposal for prophylaxis. Spine. 1998 Mar 1;23(5):615-20.
19) Singh DK, Singh N, Das PK, Malviya D. Management of postoperative discitis: a review of 31 patients. Asian Journal of Neurosurgery. 2018 Jul;13(3):703.
20) Kang BU, Lee SH, Ahn Y, Choi WC, Choi YG. Surgical site infection in spinal surgery: detection and management based on serial C-reactive protein measurements. Journal of Neurosurgery: Spine. 2010 Aug 1;13(2):158-64.
21) Jain M, Sahu RN, Gantaguru A, Das SS, Tripathy SK, Pattnaik A. Postoperative lumbar pyogenic spondylodiscitis: An institutional review. Journal of neurosciences în rural practice. 2019 Jul;10(03):511-8.
22) Silber JS, Anderson DG, Vaccaro AR, Anderson PA, McCormick P. Management of postprocedural discitis. The Spine Journal. 2002 Jul 1;2(4):279-87.
23) Frangen TM, Kälicke T, Gottwald M, Andereya S, Andress HJ, Russe OJ, Müller EJ, Muhr G, Schinkel C. Surgical management of spondylodiscitis. An analysis of 78 cases. Der Unfallchirurg. 2006 Sep 1;109(9):743-53.
24) Refaat MI, Abdallah OY. Early surgical debridement and fixation for pyogenic lumbar spondylodiscitis. Egyptian Journal of Neurosurgery. 2020 Dec;35(1):1-5.
25) Paine KW, Cauchoix J, Mcivor G, Willis WK. Lumbar spinal stenosis. Clinical Orthopaedics and Related Research®. 1974 Mar 1;99:30-50.
26) Lee CK, Vessa P, Lee JK. Chronic disabling low back pain syndrome caused by internal disc derangements. The results of disc excision and posterior lumbar interbody fusion. Spine. 1995 Feb 1;20(3):356-61.


How to Cite this Article: Islam MA, Mahbub W, Saha S, Islam AI | Fusion with stabilization for the treatment of postoperative Lumbar spondylodiscitis: Our experience | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 84-89.  https://doi.org/10.13107/bbj.2022.v03i02.045

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.

A Case Report of Aspergillus Fungal Spinal Infection in Immunocompetent Patient and Review of Literature

Volume 3 | Issue 2 | October 2022-March 2023 | page: 113-118 | Udit D. Patel, Hitesh N. Modi

DOI: https://doi.org/10.13107/bbj.2022.v03i02.049


Authors: Udit D. Patel [1], Hitesh N. Modi [1]

[1] Department of Spine Surgery, Zydus Hospitals and Healthcare Research Private Limited, Thaltej, Ahmedabad, Gujarat, India.

Address of Correspondence

Dr. Hitesh N. Modi,
Department of Spine Surgery, Zydus Hospitals and Healthcare Research Private Limited, Zydus hospital road, Thaltej, Ahmedabad, Gujarat, India.
E-mail: modispine@gmail.com


Abstract


Background: Spinal aspergillus infection is rare but can cause significant morbidity and mortality. Sometime it may mis-diagnosed as pyogenic or tuberculous infection in immunocompetent patients. Therefore, it causes delay in diagnosis and leads to spinal instability, neurological deficit, and sometimes death.
Case Report: Here we discussed a case of 68 years old female patient with severe back pain and difficulty in walking which was gradually increased over the period of time of two months. During this, she was diagnosed as koch’s spine based on MRI report and she had been started on empirical anti-tuberculous medication. But her condition was deteriorated. After that patient underwent surgical management and infected tissue sent for culture and sensitivity and histopathological examination. The report was positive for aspergillus fungal infection. she was started with anti-fungal medication and course of treatment was uneventful.
Conclusion: Early diagnosis of spinal fungal infection is often delayed in immunocompetent patients and it lead to delayed in anti-fungal management which lead to increase in morbidity and mortality.
Keywords: Aspergillus, Spinal fungal infection, Case Report


References


1. Zussman BS, Benjamin M, Penn MS, David L, Harrop MD, James S. Surgical management of fungal vertebral osteomyelitis. JHN Journal. 2011;6(2):2.
2. Casanova SR, Paulino R, Tavares J, Miranda AC, Sabino R, Veríssimo C, Toscano C, Mansinho K. Spondylodiscitis by Aspergillus nidulans: A Diagnostic Challenge. Journal of Microbiology and Infectious Diseases. 2021 Sep 1;11(03):162-5.
3. Batra S, Arora S, Meshram H, Khanna G, Grover SB, Sharma VK. A rare etiology of cauda equina syndrome. The Journal of Infection in Developing Countries. 2011;5(01):079-82.
4. Vaishya S, Sharma MS. Spinal Aspergillus vertebral osteomyelitis with extradural abscess: case report and review of literature. Surgical neurology. 2004 Jun 1;61(6):551-5.
5. Kim CW, Perry A, Currier B, Yaszemski M, Garfin SR. Fungal infections of the spine. Clinical Orthopaedics and Related Research (1976-2007). 2006 Mar 1;444:92-9.
6. Bazaz R, Denning DW. Aspergillosis: causes, types and treatment. Pharm. J. 2019;303:7927.
7. Dai G, Wang T, Yin C, Sun Y, Xu D, Wang Z, Luan L, Hou J, Li S. Aspergillus spondylitis: Case series and literature review. BMC Musculoskeletal Disorders. 2020 Dec;21(1):1-7.
8. Latgé JP, Chamilos G. Aspergillus fumigatus and Aspergillosis in 2019. Clinical microbiology reviews. 2019 Nov 13;33(1):e00140-18.
9. Perronne C, Saba J, Behloul Z, Salmon-Ceron D, Leport C, Vilde JL, Kahn MF. Pyogenic and tuberculous spondylodiskitis (vertebral osteomyelitis) in 80 adult patients. Clinical Infectious Diseases. 1994 Oct 1;19(4):746-50.
10. Yang H, Shah AA, Nelson SB, Schwab JH. Fungal spinal epidural abscess: a case series of nine patients. The Spine Journal. 2019 Mar 1;19(3):516-22.
11. Tew CW, Han FC, Jureen R, Tey BH. Aspergillus vertebral osteomyelitis and epidural abscess. Singapore Med J. 2009 Apr 1;50(4):e151-4.
12. Son JM, Jee WH, Jung CK, Kim SI, Ha KY. Aspergillus spondylitis involving the cervico-thoraco-lumbar spine in an immunocompromised patient: a case report. Korean Journal of Radiology. 2007 Oct 1;8(5):448-51.
13. Yoon KW, Kim YJ. Lumbar Aspergillus osteomyelitis mimicking pyogenic osteomyelitis in an immunocompetent adult. British Journal of Neurosurgery. 2015 Mar 4;29(2):277-9.
14. Raj KA, Srinivasamurthy BC, Nagarajan K, Sinduja MI. A rare case of spontaneous Aspergillus spondylodiscitis with epidural abscess in a 45-year-old immunocompetent female. Journal of Craniovertebral Junction and Spine. 2013 Jul;4(2):82.
15. Su KC, Chou KT, Hsiao YH, Tseng CM, Su VY, Lee YC, Perng DW, Kou YR. Measuring (1, 3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study. BMC infectious diseases. 2017 Dec;17(1):1-9.
16. Yeo SF, Wong B. Current status of nonculture methods for diagnosis of invasive fungal infections. Clinical microbiology reviews. 2002 Jul;15(3):465-84.
17. Lyons MK, Neal MT, Patel NP, Vikram HR. Progressive back pain due to Aspergillus nidulans vertebral osteomyelitis in an immunocompetent patient: surgical and antifungal management. Case Reports in Orthopedics. 2019 Jul 2;2019.
18. Patterson TF, Thompson III GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clinical infectious diseases. 2016 Aug 15;63(4):e1-60.
19. Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. New England Journal of Medicine. 2002 Aug 8;347(6):408-15.
20. Herbrecht R, Patterson TF, Slavin MA, Marchetti O, Maertens J, Johnson EM, Schlamm HT, Donnelly JP, Pappas PG. Application of the 2008 definitions for invasive fungal diseases to the trial comparing voriconazole versus amphotericin B for therapy of invasive aspergillosis: a collaborative study of the Mycoses Study Group (MSG 05) and the European Organization for Research and Treatment of Cancer Infectious Diseases Group. Clinical Infectious Diseases. 2015 Mar 1;60(5):713-20.
21. Koehler P, Tacke D, Cornely OA. Aspergillosis of bones and joints–a review from 2002 until today. Mycoses. 2014 Jun;57(6):323-35.
22. van Ooij A, Beckers JM, Herpers MJ, Walenkamp GH. Surgical treatment of aspergillus spondylodiscitis. European Spine Journal. 2000 Feb;9(1):75-9.
23. Gupta PK, Mahapatra AK, Gaind R, Bhandari S, Musa MM, Lad SD. Aspergillus spinal epidural abscess. Pediatric neurosurgery. 2001;35(1):18-23.
24. Chi CY, Fung CP, Liu CY. Aspergillus flavus epidural abscess and osteomyelitis in a diabetic patient. Journal of Microbiology, Immunology, and Infection. 2003 Jun 1;36(2):145-8.
25. Saigal G, Post MJ, Kozic D. Thoracic intradural Aspergillus abscess formation following epidural steroid injection. American journal of neuroradiology. 2004 Apr 1;25(4):642-4.
26. Chang HM, Yu HH, Yang YH, Lee WI, Lee JH, Wang LC, Lin YT, Chiang BL. Successful treatment of Aspergillus flavus spondylodiscitis with epidural abscess in a patient with chronic granulomatous disease. The Pediatric infectious disease journal. 2012 Jan 1;31(1):100-1.
27. Jiang Z, Wang Y, Jiang Y, Xu Y, Meng B. Vertebral osteomyelitis and epidural abscess due to Aspergillus nidulans resulting in spinal cord compression: Case report and literature review. Journal of international medical research. 2013 Apr;41(2):502-10.
28. McCaslin AF, Lall RR, Wong AP, Lall RR, Sugrue PA, Koski TR. Thoracic spinal cord intramedullary aspergillus invasion and abscess. Journal of Clinical Neuroscience. 2015 Feb 1;22(2):404-6.
29. Shweikeh F, Zyck S, Sweiss F, Sangtani A, Shweikeh M, Issa H, Steinmetz MP, Markarian GZ. Aspergillus spinal epidural abscess: Case presentation and review of the literature. Spinal Cord Series and Cases. 2018 Mar 7;4(1):1-9.
30. Ono R, Uehara K, Kitagawa I. Emphysematous osteomyelitis of the spine: a case report and literature review. Internal Medicine. 2018 Jul 15;57(14):2081-7.
31. Senosain-Leon V, Hidalgo-Benites A, Arriola-Montenegro J, D’Angelo-Piaggio L, Beas R. Invasive pulmonary aspergillosis with Aspergillus vertebral osteomyelitis in an HIV-infected adult: a case report. International journal of STD & AIDS. 2019 Oct;30(11):1140-2.
32. Aghapoor M, Alijani BA. Aspergillus Spondylodiscitis After Spinal Stenosis Surgery: A Case ReportA Case Report. Iranian Journal of Neurosurgery. 2019 Nov 10;5(3):155-60.
33. Takagi Y, Yamada H, Ebara H, Hayashi H, Kidani S, Okamoto S, Nakamura Y, Kitano Y, Kagechika K, Demura S, Ueno T. Aspergillus terreus spondylodiscitis following an abdominal stab wound: a case report. Journal of Medical Case Reports. 2019 Dec;13(1):1-6.
34. Perna A, Ricciardi L, Fantoni M, Taccari F, Torelli R, Santagada DA, Fumo C, Tamburrelli FC, Proietti L. Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature Review. Neurospine. 2021 Mar;18(1):23.
35. Makhdoomi R, Malik N, Charan J, Malik A, Singh S. Spinal aspergillosis: a rare complication of COVID-19 infection. Egyptian Journal of Neurosurgery. 2022 Dec;37(1):1-3.


How to Cite this Article: Patel UD, Modi HN |  A Case Report of Aspergillus Fungal Spinal Infection in Immunocompetent Patient and Review of Literature | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 113-118. https://doi.org/10.13107/bbj.2022.v03i02.049

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Patient and Parent’s Knowledge, Emotion and Expectation Evaluation in Conservatively Treated Adolescent Idiopathic Scoliosis: A Prospective Randomized Study in 200 Children by a Simple Questionnaire

Volume 3 | Issue 2 | October 2022-March 2023 | page: 96-108 | Hitesh N. Modi, Seung-Woo Suh, Jae-Young Hong, Jae-Hyuk Yang

DOI: https://doi.org/10.13107/bbj.2022.v03i02.047


Authors: Hitesh N. Modi [1, 2], Seung-Woo Suh [1], Jae-Young Hong [1], Jae-Hyuk Yang [1]

 

[1] Scoliosis Research Institute, Department of Orthopaedics, Korea University Guro Hospital, Seoul, South Korea.
[2] Department of Orthopaedics, Zydus Hospital and Healthcare Research Pvt Ltd, Ahmedabad, Gujarat, India.

Address of Correspondence

Dr Seung-Woo Suh,
Scoliosis Research Institute, Department of Orthopaedics, Korea University Guro Hospital, 80 Guro-Dong, Guro-Gu, Seoul, South Korea.
E-mail: spine@korea.ac.kr


Abstract


Objectives: To find out if any disparity of the knowledge regarding the scoliosis, treatment, psychological status and treatment satisfaction between different groups of children based on age, follow-up or treatment modality (bracing or observation) and, between patients and their parents.
Summary of Background Data. There are numerous questionnaires available in scoliosis which specifically measures either operative outcome or bracing outcomes in terms of general appearance, psychological appearance or pain scores. There is no questionnaire available that evaluate the overall general knowledge, their psychological status regarding the treatment, knowledge regarding future such as progression of curve, marriage, pregnancy and health status as well as their expectations and choices from the treatment in conservatively treated AIS patients.
Methods: Study was conducted in 200 children with adolescent idiopathic scoliosis (AIS) with age between 10 and 16 years. All 30 questions were divided into four subgroups to evaluate 1) General knowledge (Q 1-9); 2) Emotional and psychological status (Q 10-16); 3) Treatment knowledge (Q 17-25); and 4) Treatment satisfaction (Q 26-30). Results were evaluated based on treatment modality (bracing or observation); duration of follow-up (less than or more than 12 months), and age (less than or more than 13 years), and also between patients and parents.
Results: General knowledge remains the same (p>0.05) in all subgroups, while treatment knowledge was higher in parents (p<0.0001) and in patients with follow-up more than 12 months (p=0.0009) while age of patients didn’t show any difference (p=0.083). Psychological disturbances were found more in parents (p=0.046), and patients with longer follow-up (p=0.001) and higher age (p=0.002). Similarly, parents (p<0.0001), and patients with follow-up more than 12 months (0.011) and age more than 13 years (p=0.009) had higher treatment dissatisfaction. However, the treatment modality (bracing or observation) didn’t exhibit any difference (p>0.05) in any questionnaire.
Conclusion: We evaluated general and treatment knowledge, psychological and mental status and treatment satisfaction from a single and simple questionnaire in conservatively treated AIS subjects, which would provide useful information to handle the different issues involved with the disease.
Keywords: Adolescent idiopathic scoliosis, Conservative treatment, Questionnaire, Evaluation.


References


1. Lonstein JE, Carlson JM. The prediction of curve progression in untreated idiopathic scoliosis during growth. J Bone Joint Surg Am 1984; 66:1061–71.
2. Stagnara P: Les deformations du rachis. Paris,; 1976.
3. Osmond-Clarke H: Scoliosis. In The Milwaukee Brace Edited by: Blount WP and Moe JH. Baltimore, The William and Wilkins Company; 1973.
4. Hall JE: Controversial issues in spinal deformity surgery. J Pediatr Orthop 1997, 17:701-702.
5. Jacob J. Consumer access to health care information: its effect on the physician- patient relationship. Alaska Med 2002; 44:75–82.
6. Uong EC, Jeffe DB, Gozal D, et al. Development of a measure of knowledge and attitudes about obstructive sleep apnea in children (OSAKA-KIDS). Arch Pediatr Adolesc Med 2005; 159:181–6.
7. Wagner J, Lacey K, Chyun D, et al. Development of a questionnaire to measure heart disease risk knowledge in people with diabetes: the Heart Disease Fact Questionnaire. Patient Educ Couns 2005; 58:82–7.
8. Brosnan H. Nursing management of the adolescent with idiopathic scoliosis. Nurs Clin North Am 1991;26:17–31.
9. Roach JW. Nonsurgical treatment. In: Weinstein SL, ed. The Pediatric Spine: Principles and Practice. New York, NY: Raven Press; 1994: chap 23.
10. Weinstein SL, Dolan LA, Spratt KF, et al. Health and function of patients with untreated idiopathic scoliosis: a 50-year natural history study. JAMA 2003; 289:559–67.
11. Sanders JO, Harrast JJ, Kulo TR et al. The spinal appearance questionnaire. Results of reliability, validity, and responsiveness testing in patients with idiopathic scoliosis. Spine 2007; 32(24):2719-22.
12. Bridwell KH, Shufflebarger HL, Lenke LG, et al. Parents’ and patients’ preferences and concerns in idiopathic adolescent scoliosis: a cross-sectional preoperative analysis. Spine 2000; 25:2392–9.
13. Rinella A, Lenke L, Peelle M, et al. Comparison of SRS questionnaire results submitted by both parents and patients in the operative treatment of idiopathic scoliosis. Spine 2004; 29:303–10.
14. Smith PL, Donaldson S, Hedden D, et al. Parents’ and patients’ perceptions of postoperative appearance in adolescent idiopathic scoliosis. Spine 2006; 31: 2367–74.
15. Climent JM, Reig A, Sanchez J, et al. Construction and validation of a specific quality of life instrument for adolescents with spine deformities. Spine 1995; 20:2006–11.
16. Climent JM, Sanchez J. Impact of the type of brace on the quality of life of adolescents with spine deformities. Spine 1999; 24:1903–8.
17. Weiss HR, Werkmann M, Stephan C. Brace related stress in scoliosis patients- comparison of different concepts of bracing. Scoliosis 2007; 2:10.
18. Lai SM, Asher M, Burton D. Estimating SRS-22 quality of life measures with SF-36. Application in idiopathic scoliosis. Spine 2006; 31(4):473-478.
19. Khetani N, Donaldson S, Wright JG. What do patients and parents know about surgery for adolescent idiopathic scoliosis? A knowledge questionnaire. Spine 2008; 33(20):E754-758.
20. Guyatt G, Bombardier C, Tugwell P. Measuring disease-specific quality of life in clinical trials. Can Med Assoc J. 1986;134:889-895.
21. Patrick D, Deyo R. Generic and disease-specific measures in assessing health status and quality of life. Med Care. 1989;27:S217-S232.
22. Haher T, Gorup J, Shin T, et al. Results of the Scoliosis Research Society instrument for evaluation of surgical outcome in adolescent idiopathic scoliosis. Spine 1999; 24:1435–1440.
23. White S, Asher M, Lai S, et al. Patients’ perceptions of overall function, pain and appearance after primary posterior instrumentation and fusion for idiopathic scoliosis. Spine 1999; 24:1693–1700.
24. Whati LH, Senekal M, Steyn NP, et al. Development of a reliable and valid nutritional knowledge questionnaire for urban South African adolescents. Nutrition 2005;21:76–85.
25. Clayson D, Luz-Alterman S, Cataletto M, Levine DB: Long term psychological sequalae of surgically versus nonsurgically treated scoliosis. Spine 1984, 12(10):983-986.
26. MacLean WE, Green NE, Pierre CB, Ray DC: Stress and Coping with scoliosis, Psychological effects on adolescents and their families. Journal of Paediatric Orthopaedic 1989, 9(3):257-261.
27. Payne WK 3rd, Ogilvie JW, Resnick MD, Kane RL, Transfeldt EE, Blum RW: Does scoliosis have a psychological impact and does gender makes a difference? Spine 1997, 22(12):1380-4.
28. Freidel K, Petermann F, Reichel D, Steiner A, Warschburger P, Weiss HR: Quality of Life in Women With Idiopathic Scoliosis. Spine 2002, 27(4):87-91.
29. Ugwonali OF, Lomas G, Choe JC, Hyman JE, Lee FY, Vitale MG, Roye DP Jr: Effect of bracing on the quality of life of adolescents with idiopathic scoliosis. Spine 2004, 4(3):254-60.
30. Weiss HR: How much stress do scoliosis patients have because of their brace? Proceedings of the 3rd. International Conference on Conservative Management of Spinal Deformities & Scientific meeting of the SOSORT, April 7th. – 8th., Poznan, 2006 .
31. Kotwicki T, Kinel E, Stryła W, Szulc A: Estimation of the stress related to conservative scoliosis therapy: an analysis based on BSSQ questionnaires. Scoliosis 2007, 2:1.
32. Linderman M, Behm K. Cognitive strategies and self esteem as predictors of brace-wear noncomplicance in patients with idiopathic scoliosis and kyphosis. J Pediatr Orthop 1999; 19:493-499.


How to Cite this Article: Modi HN, Suh SW, Hong JY, Yang JH | Patient and Parent’s Knowledge, Emotion and Expectation Evaluation in Conservatively Treated Adolescent Idiopathic Scoliosis: A Prospective Randomized Study in 200 Children by a Simple Questionnaire | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 96-108. https://doi.org/10.13107/bbj.2022.v03i02.047

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Gorham Stout Disease- A Rare Disorder with Ambiguous Recommendations: A Systematic Review of literature.

Volume 3 | Issue 2 | October 2022-March 2023 | page: 65-77 | Ajay Krishnan, Preethesh Agrawal, Vatsal Parmar, Vikrant Chauhan, Devanand Degulmadi, Shivanand Mayi, Ravi Ranjan, Shiv Kumar Bali, Prartham C Amin, Pranav R Charde, Preety A Krishnan, Mirant R Dave, Bharat R Dave

DOI: https://doi.org/10.13107/bbj.2022.v03i02.043


Authors: Ajay Krishnan [1], Preethesh Agrawal [1], Vatsal Parmar [1], Vikrant Chauhan [1], Devanand Degulmadi [1], Shivanand Mayi [1], Ravi Ranjan [1], Shiv Kumar Bali [1], Prartham C Amin [1], Pranav R Charde [1], Preety A Krishnan [2], Mirant R Dave [1], Bharat R Dave [1]

[1] Department of Spine Surgery, Stavya Spine Hospital & Research Institute, Mithakhali, Ellisbridge, Ahmedabad, Gujarat, India.
[2] Department of Radiology, Stavya Spine Hospital & Research Institute, Mithakhali, Ellisbridge, Ahmedabad, Gujarat, India.

Address of Correspondence

Dr. Ajay Krishnan,
Department of Spine Surgery, Stavya Spine Hospital & Research Institute, Mithakhali, Ellisbridge, Ahmedabad, Gujarat, India.
E-mail: drajaykrishnan@gmail.com


Abstract


Background: Vanishing bone disease / Gorham-Stout disease (GSD) is a condition that produces deformity and instability of bone. The fibro lympho-vascular tissue replaces the bone leading to massive osteolysis and its sequelae, but the exact cause is yet unknown. The disease involves the spine infrequently, but due to the proximity of the spinal cord it can seriously affect the patient. The aim of this study is to report as a review to contribute to the diagnosis, and treatment modalities in GSD affection of spine with the reported literature available from 1983 till March 2022.
Materials & Method: This metanalysis study is focused on GSD involving the spine. The search was done in two databases PubMed and Google scholar from 1983 up to March 2022. The Study selection was done to study the demographic pattern of GSD in spine and its outcome with conservative and surgical treatment and to determine the best suitable medical treatment for stopping disease progression and achieving remission.
Results: We retrieved 72 articles from Google scholar and PubMed out of which 5 articles were excluded (90 reported cases). Heffez criteria was followed for diagnosis in all these cases (n=86, 95.5%). 57 patients (64%) were operated and 33 patients (36%) were managed conservatively. Per-operative failure to achieve a fixation/reconstruction were reported in 2 (2.53%) cases. Number of surgeries till follow-up were average 1.70+ 1.23 (1-5) surgeries. The average follow-up of cases reported was 47.1+ 48.9 (3-240 months). Union was documented in 10 cases (3.4%). 9 of these cases needed additional bone graft/substitute. Bisphosphonates(n=40), sirolimus (n=5), interferon (n=17), radiotherapy (n= 31) and beta-blockers (n=4) were given in medications. 23 patients had remission. Death occurred in 17 patients (18.88%).
Conclusion: Surgery is needed frequently. Failure of fixations, achieving union and remission are daunting and ’off  label” therapies are the dictum. Radiotherapy has been used more frequently with or without bisphosphonates. Though promising medical treatment are evolving and focus of treatment is directed towards anti-angiogenic, anti-osteolytic and anabolic therapy, but no standard treatment recommendations can be made out from existing literature.
Keywords: Vanishing bone disease, Gorham stout, Osteolysis, Spine, Deformity, Sirolimus, TNF


References


1. Dickson GR, Hamilton A, Hayes D, Carr KE, Davis R, Mollan RAB. An investigation of vanishing bone disease. Bone. 1990;11(3):205–210.
2. Gorham lw sa. Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone); its relation to hemangiomatosis. J Bone Jt Surg Am. 1995;37(5):985–1004.
3. Nikolaou VS, Chytas D, Korres D, Efstathopoulos N. Vanishing bone disease (gorham-stout syndrome): A review of a rare entity. World J Orthop. 2014;5(5):694–698.
4. Sekharappa V, Arockiaraj J, Amritanand R, Krishnan V, David KS, David SG. Gorham’s disease of spine. Asian Spine J. 2013;7(3):242–247.
5. Momanu A, Caba L, Gorduza NC, Arhire OE, Popa AD, Ianole V, et al. Gorham-stout disease with multiple bone involvement—challenging diagnosis of a rare disease and literature review. Med. 2021;57(7):1–11.
6. Dellinger MT, Garg N, Olsen BR. Viewpoints on vessels and vanishing bones in Gorham-Stout disease. Bone [Internet]. 2014;63:47–52.
7. Grönroos M, Palomäki A. Young adult with Gorham’s disease presenting in an emergency department: a case report. J Med Case Rep. 2021;15(1):1–4.
8. Du CZ, Li S, Xu L, Zhou QS, Zhu ZZ, Sun X, et al. Spinal Gorham-Stout syndrome: Radiological changes and spinal deformities. Quant Imaging Med Surg. 2019;9(4):565–578.
9. Patel DV. Gorham’s disease or massive osteolysis. Clin Med Res. 2005;3:65–74.
10. Avelar RL, Martins VB, Antunes AA, de Oliveira Neto PJ AE. Use of zoledronic acid in the treatment of Gorham’s disease. Int J Pediatr Otorhinolaryngol. 2010;74:319–22.
11. Koto K, Inui K, Itoi M, Itoh K. Gorham-Stout disease in the rib and thoracic spine with spinal injury treated with radiotherapy, zoledronic acid, vitamin D, and propranolol: A case report and literature review. Mol Clin Oncol. 2019;11(6):551–556.
12. Dominguez R, Washowich TL. Pediatric Radiology plain film , CT , and MRI findings of two cases. 1994;316–318.
13. Tateda S, Aizawa T, Hashimoto K, Kanno H, Ohtsu S, Itoi E, et al. Successful management of gorham-stout disease in the cervical spine by combined conservative and surgical treatments: A case report. Tohoku J Exp Med. 2017;241(4):249–254.
14. Tilling G SB. Disappearing bone disease, Morbus Gorham: report of a case. Acta Orthop Scand. 1968;39:398–406.
15. Ali Akbar Esmailiejah, Naser Kamalian MA. Temporary Paraplegia resulting from Groham’s disease involving the third lumbar vertebrae and proximal femur: A five year Follow-up and review of the literarture. Arch Iran Med. 2013;16(11):686–690.
16. Paley MD, Lloyd CJ PC. Total mandibular reconstruction for massive osteolysis of the mandible. Br J Oral Maxillofac Surg. 2005;43:166–168.
17. Vinée P, Tanyü MO, Hauenstein KH, Sigmund G, Stöver B AC. CT and MRI of Gorham syndrome. J Comput Assist Tomogr. 1994;18:985–989.
18. Yoo SY, Hong SW. Chung HW, Choi JA, Kim CJ KH. MRI of the Gorham’s disease: finding in two cases. Skelet Radiol. 2002;31:301–306.
19. Heffez L, Feeney JE, Carter BL. Perspectives on massive osteolysis: report of a case and review of the literature. Oral Surgery, Oral Med Oral Pathol. 1993;55(4):331–343.
20. Ruggieri P, Montalti M, Angelini A, Alberghini M, Mercuri M. Gorham-Stout disease: The experience of the Rizzoli Institute and review of the literature. Skeletal Radiol. 2011;40(11):1391–1397.
21. Chang-Zhi Du, Song Li, Liang Xu, Qing-Shuang Zhou, Ze-Zhang Zhu, Xu Sun YQ. Spinal Gorham-Stout syndrome: radiological changes and spinal deformities. Quant Imaging Med Surg. 2019;9(4):565–578.
22. Ibrahim Saeed Gataa, Noroz Hama R. Nader Y, Abdallah DT. Massive Craniofacial Gorham Disease Treated Successfully by Cisplatin and 5-Fluorouracil With Ten Years of Follow-Up: A Case Report and Literature Review. J Oral Maxillofac Surg. 2016;74(9):1774–1782.
23. DevlinRD, BoneHG3rd R. Interleukin-6: a potential mediator of the massive osteolysis in patients withGorham– Stout disease. J Clin EndocrinolMetab. 1996;81:1893–1897.
24. Colucci S, Taraboletti G, Primo L, Viale A, Roca C, Valdembri D, Geuna M, Pagano M, Grano M, Pogrel AM et al. Gorham‑Stout syndrome: A monocyte‑mediated cytokine propelled disease. J Bone Min Res. 2006;21:207–18.
25. Dupond J-L, Bermont L, Runge M de BM. Plasma VEGF determination in disseminated lymphangiomatosis-Gorham– Stout syndrome. A marker of activity? A case report with a 5 years follow-up. Bone. 2010;46:873–876.
26. Kulenkampff HA, Richter GM, Hasse WE et al. Massive pelvic osteolysis in the Gorham-Stout syndrome. Int Orthop. 1990;14:361–366.
27. Cannon SR. Massive osteolysis. A review of seven cases. J Bone Jt Surg – Ser B. 1986;68(1):24–28.
28. Hardegger F, Simpson LA SG. The syndrome of idiopathic osteolysis. Classification, review, and case report. J Bone Jt Surg Br. 1985;67:88–93.
29. Lee BB, Rockson SG BJ. Lymphedema: a concise compendium of theory and practice. Springer. 2018;
30. P.J. L, Saifuddin A, Webb PJ, Mitchell N, Ramani P. Gorham’s disease of the spine. Skeletal Radiol. 1996;25:403–405.
31. Liu S, Zhou X, Song A, Kong X, Wang Y, Liu Y. Successful treatment of Gorham-Stout syndrome in the spine by vertebroplasty with cement augmentation: A case report and literature review. Med (United States). 2018;97(29):1–6.
32. Kahn HJ, Bailey D MA. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi’s sarcoma and a subset of angiosarcomas. Mod Pathol. 2002;15(4):434–440.
33. Krishnan A, Raj A, Degulmadi D, Mayi S, Rai R, Bali SK, et al. Gorham-Stout disease: A multirod lumbar reconstruction with off-label suppression-remission therapy. Surg Neurol Int. 2022;13(136):1–5.
34. Bouloux GF, Walker DM MG. Massive osteolysis of the mandible: Report of a case with multifocal bone loss. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87(3):357–361.
35. Sharma A, Iyer N, Mittal A, Das D SS. Vanishing mandible. J Oral Sci. 2012;52(3):513–516.
36. Tong A, Leung T, Surgery PC. Management of massive osteolysis of the mandible: a case report. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2010;109(2):238–41.
37. Gondivkar SM GA. Gorham-Stout syndrome: a rare clinical entity and review of literature. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2010;109(2):41–48.
38. Brodszki N, Länsberg JK, Dictor M, Gyllstedt E, Ewers SB, Larsson MK, et al. A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax. Acta Paediatr Int J Paediatr. 2011;100(11):1448–1453.
39. Tena-Sanabria ME, Jesús-Mejenes LY, Fuentes-Herrera G, Álvarez-Martínez FA, Victorio-García NP, Núñez-Enríquez JC. A report of two children with Gorham-Stout disease. BMC Pediatr. 2019;19(1):1–7.
40. Vanhoenacker FM, De Vuyst D, Vandervliet E, Veyt A, Vangeneugden J. Paget’s disease with vanishing bone pattern and spinal fusion. J Belge Radiol. 2007;90(5):388–390.
41. Damron TA, Brodke DS, Heiner JP, Swan JS DS. Gorham’s disease (Gorham-Stout syndrome) of scapula. Skelet Radiol. 1993;22:464–467.
42. Martín Noguerol T, Barousse R, Socolovsky M LA. A. Quantitative magnetic resonance (MR) neurography for evaluation of peripheral nerves and plexus injuries. Quant Imaging Med Surg. 2017;7:398–421.
43. Mawk JR, Obukhov SK, Nichols WD, Wynne TD, Odell JM, Urman SM. Successful conservative management of Gorham disease of the skull base and cervical spine. Child’s Nerv Syst. 1997;13:622–625.
44. Granado Peña JM, Báez Marrero O, Sosa Henríquez M. Gorham’s disease of the cervical spine. Case report. Neurocirugia. 1995;6(2):156–160.
45. Boyer, P.; Bourgeois, P.; Boyer, O.; Catonne, Y.; Saillant G. Massive Gorham-Stout syndrome of the pelvis. Clin Rheumatol. 2005;24:551–555.
46. Aizawa T, Sato T, Kokubun S. Gorham disease of the spine: A case report and treatment strategies for this enigmatic bone disease. Tohoku J Exp Med. 2005;205(2):187–196.
47. Kakuta Y, Iizuka H, Kobayashi R, Iizuka Y, Takahashi T, Mohara J, et al. Gorham disease of the lumbar spine with an abdominal aortic aneurysm: A case report. Spine J. 2014;14(1):5–9.
48. Chong Ng L, Sell P. Gorham disease of the cervical spine-a case report and review of the literature. Spine (Phila Pa 1976). 2003;28(18):355–358.
49. Barman A, Bhide R, Viswanathan A, George J, Thomas R, Tharion G. Gorham’s disease of the spine. NeuroRehabilitation. 2013;33(1):121–126.
50. Tie ML, Poland GA RE 3rd. Chylothorax in Gorham’s syndrome. A common complication of a rare disease. Chest. 1994;105(1):208–213.
51. Ellati R, Attili A, Haddad H, Al-Hussaini M SA. Novel approach of treating Gorham-Stout disease in the humerus: Case report and review of literature. Eur Rev Med Pharmacol Sci. 2016;20(3):426–432.
52. Mo AZ, Trenor CC, Hedequist DJ. Sirolimus Therapy as Perioperative Treatment of Gorham-Stout Disease in the Thoracic Spine A Case Report. JBJS Case Connect. 2018;8(3):1-7.
53. Manisali, M. & Ozaksoy D. Gorham disease: correlation of MR findings with histopathologic changes. Eur Radiol. 1998;8:1647–1650.
54. William H. Edwards, Roby c.thompson E varsa. Lymphangiomatosis and massive osteolysis of the cervical spine. Clin Orthop Relat Res. 1983;222–9.
55. Dunbar SF, Rosenberg A, Mankin H, Rosenthal D, Suit HD. Gorham’s massive osteolysis: the role of radiation therapy and a review of the literature. International Journal of Radiation Oncology* Biology* Physics. 1993 Jun 15;26(3):491-497.
56. Drewry GR, Martinez CR, Brantley SG. Gorham disease of the spine. Spine (Phila Pa 1976). 1994;19(19):2213–22.
57. Foult H, Goupille P, Aesch B, Valat JP, Burdin P JM. Massive osteolysis of the cervical spine. A case report. Spine (Phila Pa 1976). 1995;20(14):1636–1639.
58. Hans Hagberg, Kristina Lamberg GÅ. a-2b interferon and oral clodronate for Gorham’s disease. Lancet. 1997;350:1822–1823.
59. Khosrovi H, Ortiz O, Kaufman HH, Schocket SS, Reddy GN, Simmons D. Massive osteolysis of the skull and upper cervical spine: Case report and review of the literature. J Neurosurg. 1997;87(5):773–780.
60. Bode-Lesniewska B, Hochstetter A von, Exner GU, Hodler J. Gorham-Stout disease of the shoulder girdle and cervico-thoracic spine: fatal course in a 65-year-old woman. Skelet Radiol. 2002;31:724–729.
61. Duffy BM, Manon R, Patel RR, Welsh JS. A case of Gorham’s disease with chylothorax treated curatively with radiation therapy. Clin Med Res. 2005;3(2):83–86.
62. Takahashi A, Ogawa C, Kanazawa T, Watanabe H, Suzuki M, Suzuki N, et al. Remission induced by interferon alfa in a patient with massive osteolysis and extension of lymph-hemangiomatosis: A severe case of Gorham-Stout syndrome. J Pediatr Surg. 2005;40(3):47–50.
63. Girn HRS, Towns G, Chumas P, Holland P, Chakrabarty A. Gorham’s disease of skull base and cervical spine – Confusing picture in a two year old. Acta Neurochir (Wien). 2006;148(8):909–913.
64. B. Kai, A. Ryan, P.L. Munk PD. Gorham disease of bone: three cases and review of radiological features. Clin Radiol. 2006;61:1058–1064.
65. Lekovic GP, Mariwalla NR, Horn EM, Chang S, Rekate HL, Theodore N. Skeletal dysplasia involving the subaxial cervical spine: Report of two cases and review of the literature. Neurosurgical focus. 2006 Feb 1;20(2):1-6.
66. Lehmann G, Pfeil A, Böttcher J, Kaiser WA, Füller J, Hein G, et al. Benefit of a 17-year long-term bisphosphonate therapy in a patient with Gorham-Stout syndrome. Arch Orthop Trauma Surg. 2009;129(7):967–972.
67. Kose M, Pekcan S, Dogru D, Akyuz C, Ozcelik U, Ozsurekci Y, et al. Gorham-Stout syndrome with chylothorax: Successful remission by interferon alpha-2b. Pediatr Pulmonol. 2009;44(6):613–615.
68. Sarah Mowry, MD; Rinaldo Canalis, MD F. Gorham-Stout Disease of the Temporal Bone. Laryngoscope. 2010;120:598–600.
69. Adler F, Gupta N, Hess CP, Dowd CF, Dillon WP. Intraosseous CSF fistula in a patient with Gorham disease resulting in intracranial hypotension. Am J Neuroradiol. 2011;32(11):198–200.
70. Deveci M, Nagihan İ, Çorapç F. Gorham-Stout Syndrome with Chylothorax in a Six-Year-Old Boy. 2011;78(June):737–739.
71. Heyd R, Micke O, Surholt C, Berger B, Martini C, Füller J, Schimpke T, Seegenschmiedt MH, German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD. Radiation therapy for Gorham-Stout syndrome: results of a national patterns-of-care study and literature review. International Journal of Radiation Oncology* Biology* Physics. 2011 Nov 1;81(3):179-185.
72. Rajendra Kumar Sahoo, Balavenkatasubramanian Jagannathan G, Palanichamy VN. Anaesthetic consideration in patients with Gorham ’ s syndrome : A case report and review of the literature. 2012;56(4):391–394.
73. Noda M, Endo C, Hoshikawa Y, Ishibashi N, Suzuki T, Okada Y, et al. Successful management of intractable chylothorax in Gorham-Stout disease by awake thoracoscopic surgery. Gen Thorac Cardiovasc Surg. 2013;61(6):356–358.
74. Zheng MW, Yang M, Qiu JX, Nan XP, Huang LY, Zhang WD, Gong L, Huang ZZ. Gorham-Stout syndrome presenting in a 5-year-old girl with a successful bisphosphonate therapeutic effect. Experimental and Therapeutic Medicine. 2012 Sep 1;4(3):449-451.
75. Kilicoglu ZG, Kis NK, Aker FV, Berkman MZ, Simsek MM. Gorham disease of the craniocervical junction: X-ray, computed tomography, and magnetic resonance imaging findings. The Spine Journal. 2013 May 1;13(5):11-14..
76. Maillot C, Cloche T, Le Huec JC. Thoracic osteotomy for Gorham-Stout disease of the spine: a case report and literature review. European Spine Journal. 2014;27(9):2285-2290.
77. Molina EJ, Niederstadt T, Ruland V, Kayser G, Stummer W, Ewelt C, Rössler J. Cerebrospinal fluid leakage in Gorham-Stout disease due to dura mater involvement after progression of an osteolytic lesion in the thoracic spine: Case report. Journal of Neurosurgery: Spine. 2014 Dec 1;21(6):956-960.
78. Vered Nir, MD, , Ludmila Guralnik, MD, Galit Livnat, MD, Ronen Bar-Yoseph M, Fahed Hakim, MD, Anat Ilivitzki, MD, and Lea Bentur M. Propranolol as a Treatment Option in Gorham–Stout Syndrome: A Case Report. Pediatr Pulmonol. 2014;49:417–419.
79. Kohno M, Aota Y, Kawai T, Murata H, Saito T. Surgical Treatment of Gorham’s Disease with Massive Osteolysis of the Skull and Cervical Spine: A Case Report and Review of Literature. NMC Case Rep J. 2015;2(2):80–84.
80. Ganal-Antonio AK, Samartzis D, Bow C, Cheung KM, Luk KD, Wong YW. Disappearing bone disease of the humerus and the cervico-thoracic spine: a case report with 42-year follow-up. The Spine Journal. 2016 Feb 1;16(2):67-75.
81. Carbó E, Riquelme Ó, García A, González JL. Vertebroplasty in a 10-year-old boy with Gorham–Stout syndrome. Eur Spine J. 2015;24:590–593.
82. Kim MK, Hong JR, Kim SG, Lee SK. Fatal Progression of Gorham Disease: A Case Report and Review of the Literature. J Oral Maxillofac Surg. 2015;73(12):2352–2360.
83. Pn G, Ac D, An P. A Rare Case of Progressive Gorham’s Disease of Right Shoulder Girdle and Cervical Spine in A Child: 10 Year Follow-up and A Review of Literature. J Orthop case reports. 2015;5(4):30–33.
84. Rössler J, Saueressig U, Kayser G, Von Winterfeld M, Klement GL. Personalized therapy for generalized lymphatic anomaly/gorham-stout disease with a combination of sunitinib and taxol. J Pediatr Hematol Oncol. 2015;37(8):481–485.
85. Adam Schell, John M. Rhee, Abigail Allen, Lindsay Andras FZ. Surgical management of gorham disease involving the upper cervical spine with occipito-cervical-thoracic fusion: a case report. Spine J. 2016;1–11.
86. Srivastava SK, Aggarwal RA, Nemade PS, Bhoale SK. Vanishing bone disease of chest wall and spine with kyphoscoliosis and neurological deficit: A case report and review of literature. Indian J Orthop. 2017;51(1):107–114.
87. Alexandre Jaccard, César Macedo, Gabriel Castro AG. Thoracic spine dislocation in Gorham–Stout Syndrome: Case report and literature review. Surg Neurol Int. 2018;9(223):1–3.
88. Wang P, Liao W, Cao G, Jiang Y. A rare case of Gorham-stout syndrome involving the thoracic spine with progressive bilateral chylothorax: A case report. BMC Musculoskelet Disord. 2019;20(1):1–6.
89. Jung Hwa Kim, MD, Do Heum Yoon, MD. PhD, Keung Nyun Kim, MD. PhD DA, Shin, MD. PhD, Seong Yi, MD. PhD, Jiin Kang, MD, Yoon Ha MP. Surgical management of Gorham-Stout disease in cervical compression fracture with cervico-thoracic fusion: A Case report and review of literature. World Neurosurg. 2019;129:277–281.
90. Barbagli G, Barni I, Romoli S. A rare case of spine disappearing bone disease: Lesson learned and review of the literature. Interdisciplinary Neurosurgery. 2019 Sep 1;17:79-83.
91. Simon F, Luscan R, Khonsari RH, Toubiana J, Belhous K, James S, Blauwblomme T, Zerah M, Denoyelle F, Donadieu J, Couloigner V. Management of Gorham Stout disease with skull-base defects: case series of six children and literature review. International Journal of Pediatric Otorhinolaryngology. 2019 Sep 1;124:152-156.
92. Chang K, Yang M, Li B, Huang H. Surgical management of Gorham‑Stout syndrome involving the cervical spine with bilateral pleural effusion: A case report and literature review. Exp Ther Med. 2020;19:3851–3855.
93. Hana Yokoi, Vikram Chakravarthy, Benjamin Whiting, Scott E. Kilpatrick, Tsulee Chen AK. Gorham-Stout disease of the spine presenting with intracranial hypotension and cerebrospinal fluid leak: A case report and review of the literature. Surg Neurol Int. 2020;11(466):1–4.
94. Chloe Gui1, Brett Rocos, Laura-Nanna Lohkamp, Angela Cheung, Robert Bleakney EM. Utility of the spinal instability neoplastic score to identify patients with Gorham-Stout disease requiring spine surgery. Surg Neurol Int. 2021;12(227):1–3.
95. Toga A, Watanabe K, Suzuki S, Nori S, Tsuji O, Nagoshi N, et al. Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy: A Case Report. JBJS case Connect. 2021;11(1):1–5.
96. Harman YG and F. The loneliness of a long-distance runner. A ten-year survey of a patient diagnosed with Gorham-Stout syndrome at the occipitocervical junction. Br J Neurosurg. 2021;1–4.
97. Aleksey Evsyukov, Murodzhon Kosimshoev, Yuliy Kubetskyi EN and JR. Surgical treatment of a patient with Gorham-Stout disease of craniovertebral junction: case report and literature review. Br J Neurosurg. 2021;1–6.
98. Ashley Ann Thompson SP. Gorham- Stout disease of the mandible, manubrium and cervical spine presenting as bilateral chylothorax. BMJ Case Rep. 2021;14(1):1–3.


How to Cite this Article: Krishnan A, Agrawal P, Parmar V, Chauhan V, Degulmadi D, Mayi S, Ranjan R, Bali SK, Amin PC, Charde PR, Krishnan PA, Dave MR, Dave BR | Gorham Stout Disease- A Rare Disorder with Ambiguous Recommendations: A Systematic Review of literature | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 65-77.  https://doi.org/10.13107/bbj.2022.v03i02.043

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Application of Intra Operative Ultrasound in Spine Surgery

Volume 3 | Issue 2 | October 2022-March 2023 | page: 51-54 | Rakeshkumar C. Luhana, Jinil N. Doshi

DOI: https://doi.org/10.13107/bbj.2022.v03i02.041


Authors: Rakeshkumar C. Luhana [1], Jinil N. Doshi [1]

[1] Department of Spine Surgery, Venus Superspeciality Hospital, Vadodara, Gujarat, India.

Address of Correspondence

Dr. Rakeshkumar Luhana,
Department of Spine Surgery, Venus Superspeciality Hospital, Vadodara, Gujarat, India.
E-mail:rcluhana@gmail.com


Abstract


Objective: Intraoperative ultrasound is a real time imaging modality. Though was introduced in 1980s, not widely used. It is applicable for Intradural lesions as well as pathology ventral to cord, while doing posterior approach and helps us to make surgery safer. Our objective is to share technique as well as our experience of intra operative ultrasound by sharing illustrative cases.
Method: our Surgical cases were reviewed and identified cases where we used intraoperative ultrasound. Illustrative cases were selected and compiled.
Results: This article describes technique of intra operative ultrasound and several illustrative cases were demonstrated.
Conclusion: Intraoperative ultrasound is a real time imaging tool and can be used for various indications especially for intradural lesions and addressing ventral pathology from posterior routes.
Keywords: Intra operative ultrasound, Real time imaging, Intra operative adjunct


References


1. Dohrmann GJ, Rubin JM. Intraoperative ultrasound imaging of the spinal cord: syringomyelia, cysts, and tumors—a preliminary report. Surg Neurol. 1982;18:395–399.
2. Braun IF, Raghavendra BN, Kricheff II. Spinal cord imaging using real-time high-resolution ultrasound. Radiology. 1983;147:459–465.
3. Knake JE, Gabrielsen TO, Chandler WF, Latack JT, Gebarski SS, Yang PJ. Real-time sonography during spinal surgery. Radiology. 1984;151:461–465.
4. Rubin JM, Dohrmann GJ. The spine and spinal cord during neurosurgical operations: real-time ultrasonography. Radiology. 1985;155:197–200.
5. Montalvo BM, Quencer RM. Intraoperative sonography in spinal surgery: current state of the art. Neuroradiology. 1986;28:551–590.
6. Pasto ME, Rifkin MD, Rubenstein JB, Northrup BE, Cotler JM, Goldberg BB. Real-time ultrasonography of the spinal cord: intraoperative and postoperative imaging. Neuroradiology. 1984;26:183–187.
7. Quencer RM, Montalvo BM, Eismont FJ, Green BA. Intraoperative spinal sonography in thoracic and lumbar fractures: evaluation of Harrington rod instrumentation. AJR Am J Roentgenol. 1985;145:343–349.
8. Quencer RM, Montalvo BM, Green BA, Eismont FJ. Intraoperative spinal sonography of soft-tissue masses of the spinal cord and spinal canal. AJR Am J Roentgenol. 1984;143:1307–1315.
9. Quencer RM, Morse BM, Green BA, Eismont FJ, Brost P. Intraoperative spinal sonography: adjunct to metrizamide CT in the assessment and surgical decompression of posttraumatic spinal cord cysts. AJR Am J Roentgenol. 1984;142:593–601.
10. Rubin JM, Dohrmann GJ. Work in progress: intraoperative ultrasonography of the spine. Radiology. 1983;146:173–175.
11. McGahan JP, Benson D, Chehrazi B, Walter JP, Wagner FC., Jr Intraoperative sonographic monitoring of reduction of thoracolumbar burst fractures. AJR Am J Roentgenol. 1985;145:1229–1232.
12. Sosna J, Barth MM, Kruskal JB, Kane RA. Intraoperative sonography for neurosurgery. J Ultrasound Med. 2005;24:1671–1682.
13. Toktas ZO, Sahin S, Koban O, Sorar M, Konya D. Is intraoperative ultrasound required in cervical spinal tumors? A prospective study. Turk Neurosurg. 2013;23:600–606.
14. Harel R, Knoller N. Intraoperative spine ultrasound: application and benefits. Eur Spine J. 2016;25:865–869..
15. Prada F, Vetrano IG, Filippini A, et al. Intraoperative ultrasound in spinal tumor surgery. J Ultrasound. 2014;17:195–202.
16. Zhou H, Miller D, Schulte DM, et al. Intraoperative ultrasound assistance in treatment of intradural spinal tumours. Clin Neurol Neurosurg. 2011;113:531–537.
17. Bozinov O, Burkhardt JK, Woernle CM, et al. Intra-operative high frequency ultrasound improves surgery of intramedullary cavernous malformations. Neurosurg Rev. 2012;35:269–275.
18. Sciubba DM, Liang D, Kothbauer KF, Noggle JC, Jallo GI. The evolution of intramedullary spinal cord tumor surgery. Neurosurgery. 2009;65:84–91.
19. Regelsberger J, Fritzsche E, Langer N, Westphal M. Intraoperative sonography of intra-and extramedullary tumors. Ultrasound Med Biol. 2005;31:593–598.
20. Iacopino DG, Conti A, Giusa M, Cardali S, Tomasello F. Assistance of intraoperative microvascular doppler in the surgical obliteration of spinal dural arteriovenous fistula: cases description and technical considerations. Acta Neurochir. 2003;145:133–137.
21. Friedman JA, Wetjen NM, Atkinson JL. Utility of intraoperative ultrasound for tumors of the Cauda equina. Spine (Phila Pa 1976). 2003;28:288–290.
24. Tekula F, Pritz MB, Kopecky K, Willing SJ. Usefulness of color Doppler ultrasound in the management of a spinal arteriovenous fistula. Surg Neurol. 2001;56:304–307.
25. Lunardi P, Acqui M, Ferrante L, Fortuna A. The role of intraoperative ultrasound imaging in the surgical removal of intramedullary cavernous angiomas. Neurosurgery. 1994;34:520–523.
26. Matsuzaki H, Tokuhashi Y, Wakabayashi K, Toriyama S. Clinical values of intraoperative ultrasonography for spinal tumors. Spine (Phila Pa 1976). 1992;17:1392–1399.
27. Kawakami N, Mimatsu K, Kato F. Intraoperative sonography of intramedullary spinal cord tumours. Neuroradiology. 1992;34:436–439.
28. Epstein FJ, Farmer JP, Schneider SJ. Intraoperative ultrasonography: an important surgical adjunct for intramedullary tumors. J Neurosurg. 1991;74:729–733.
29. Platt JF, Rubin JM, Chandler WF, Bowerman RA, DiPietro MA. Intraoperative spinal sonography in the evaluation of intramedullary tumors. J Ultrasound Med. 1988;7:317–325.
30. Harrop JS, Ganju A, Groff M, Bilsky M. Primary intramedullary tumors of the spinal cord. Spine (Phila Pa 1976). 2009;34(22 suppl):S69–S77.
31. Nishimura Y, Thani NB, Tochigi S, Ahn H, Ginsberg HJ. Thoracic discectomy by posterior pedicle-sparing, transfacet approach with real-time intraoperative ultrasonography: clinical article. J Neurosurg Spine. 2014;21:568–576.
32. Seichi A, Chikuda H, Kimura A, et al. Intraoperative ultrasonographic evaluation of posterior decompression via laminoplasty in patients with cervical ossification of the posterior longitudinal ligament: correlation with 2-year follow-up results. J Neurosurg Spine. 2010;13:47–51.
33. Aoyama T, Hida K, Akino M, Yano S, Iwasaki Y. Detection of residual disc hernia material and confirmation of nerve root decompression at lumbar disc herniation surgery by intraoperative ultrasound. Ultrasound Med Biol. 2009;35:920–927.
34. Tokuhashi Y, Matsuzaki H, Oda H, Uei H. Effectiveness of posterior decompression for patients with ossification of the posterior longitudinal ligament in the thoracic spine: usefulness of the ossification-kyphosis angle on MRI. Spine (Phila Pa 1976). 2006;31:E26–E30.
35. Mueller LA, Degreif J, Schmidt R, et al. Ultrasound-guided spinal fracture repositioning, ligamentotaxis, and remodeling after thoracolumbar burst fractures. Spine (Phila Pa 1976). 2006;31:E739–E746.
36. Matsuyama Y, Kawakami N, Yanase M, et al. Cervical myelopathy due to OPLL: clinical evaluation by MRI and intraoperative spinal sonography. J Spinal Disord Tech. 2004;17:401–404.
37. Lazennec JY, Saillant G, Hansen S, Ramare S. Intraoperative ultrasonography evaluation of posterior vertebral wall displacement in thoracolumbar fractures. Neurol Med Chir (Tokyo). 1999;39:8–14.
38. Blumenkopf B, Daniels T. Intraoperative ultrasonography (IOUS) in thoracolumbar fractures. J Spinal Disord. 1988;1:86–93.
39. Randel S, Gooding GA, Dillon WP. Sonography of intraoperative spinal arteriovenous malformations. J Ultrasound Med. 1987;6:539–544.
40. Viren s, Muhammad A, Yuri a et al. Use of intraoperative ultrasound in spine surgery. Global Spine Journal.2017;7(7);648-656
41. Mario G, Nikolaos S, Allan R et al. Intraoperative ultrasound in Spine surgery: history, current applications, future developments. Quant Imaging Med Surg 2018;8(3):261-267
42. Ahmed A, Hussam A, Alaa A et al. The utility of ultrasound for surgical spinal decompression. Med Ultrason 2015;17(2): 211-218


How to Cite this Article: Luhana R, Doshi J |  Application of Intra Operative Ultrasound in Spine Surgery | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 51-54. https://doi.org/10.13107/bbj.2022.v03i02.041

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A Prospective Study to Find Out the Association between Supine Lying Low Back Pain and Retrolisthesis

Volume 3 | Issue 1 | April-September 2022 | page: 42-46 | Bharat R. Dave, Shivanand C. Mayi, Ajay Krishnan, Ramneesh Kohli, Devanand Degulmadi, Ravi Ranjan Rai, Mirant B. Dave

DOI: https://doi.org/10.13107/bbj.2022.v03i01.039


Authors: Bharat R. Dave [1], Shivanand C. Mayi [1], Ajay Krishnan [1], Ramneesh Kohli [1], Devanand Degulmadi [1], Ravi Ranjan Rai [1], Mirant B. Dave [1]

[1] Department of Spine Surgery, Stavya Spine Hospital & Research Institute, Mithakali, Ahmedabad, Gujarat, India.

Address of Correspondence

Dr. Shivanand C. Mayi,
Consultant Spine Surgeon, Stavya Spine Hospital & Research Institute, Mithakali, Ahmedabad, Gujarat, India.
E-mail: drshivanandmayi@gmail.com


Abstract


Objectives: The objectives of this study was to test the primary hypothesis that “retrolisthesis causes supine lying low back pain (LBP).”
Methods: Patients with history of chronic back pain (>12 weeks) who presented to the hospital outpatient department were evaluated. Patients with history of supine lying exaggeration of symptoms were specifically asked for duration, for which they can comfortably lie in supine position. Retrolisthesis in this study was measured on MRI mid sagittal image by measuring the slip percent. Slip percent of more than 8% was labeled as retrolisthesis. Statistical analysis was done using SPSS software.
Results: Average age of the study population was 41.46 ± 10.82 years. All the study participants had the history of supine lying LBP for 50 ± 54.51 weeks. About 94.78% (n = 115) of the study subjects had retrolisthesis on MRI. About 46.08% (n = 115) were house wives. L5-S1 was the most commonly involved level, three patients had no instability, and three patients had anterolisthesis. Duration of time up to which the patients can lie down in supine position was not statistically significant when analyzed with the VAS values for supine lying LBP and the slip percent.
Conclusion: The presence of supine lying LBP in an individual should be strongly considered for the underlying subtle instability at the lumbar intervertebral segments and diagnostic evaluation should be performed to rule out retrolisthesis.
Keywords: Retrolisthesis, Low back pain, supine lying, Lumbar instability, Vertebral slippage, Lateral stenosis, Dynamic radiograph.


References


1. Rothman SLG, Glenn WV Jr., Kerber CW. Multiplanar CT in the evaluation of degenerative spondylolisthesis. A review of 150 cases. Comput Radiol 1985;9:223-32.
2. Lee C, Woodring JH, Rogers LF, Kim KS. The radiographic distinction of degenerative slippage (spondylolisthesis and retrolisthesis) from traumatic slippage of the cervical spine. Skeletal Radiol 1986;15:439-43.
3. Ahmed A, Mahesh BH, Shamshery PK, Jayaswal A. Traumatic retrolisthesis of the L4 vertebra. J Trauma 2005;58:393-4.
4. Barrey C, Roussouly P, Le Huec JC, D’Acunzi G, Perrin G. Compensatory mechanisms contributing to keep the sagittal balance of the spine. Eur Spine J 2013;22 Suppl 6:S834-41.
5. Berlemann U, Jeszenszky DJ, Bühler DW, Harms J. Mechanisms of retrolisthesis in the lower lumbar spine. A radiographic study. Acta Orthop Belg 1999;65:472-7.
6. Shen M, Razi A, Lurie JD, Hanscom B, Weinstein J. Retrolisthesis and lumbar disc herniation: A pre operative assessment of patient function. Spine J 2007;7:406 13.
7. Iguchi T, Wakami T, Kurihara A, Kasahara K, Yoshiya S, Nishida K. Lumbar multilevel degenerative spondylolisthesis: Radiological evaluation and factors related to anterolisthesis and retrolisthesis. J Spinal Disord Tech 2002;15:93-9.
8. Barrey C, Roussouly P, Perrin G, Le Huec JC. Sagittal balance disorders in severe degenerative spine. Can we identify the compensatory mechanisms? Eur Spine J 2011;20 Suppl 5:626-33.
9. Barrey C, Jund J, Perrin G, Roussouly P. Spinopelvic alignment of patients with degenerative spondylolisthesis. Neurosurgery 2007;61:981-6.
10. Deyo RA, Bass JE. Lifestyle and low-back pain. The influence of smoking and obesity. Spine 1989;14:501-6.
11. Videman T, Battie M. A critical review of the epidemiology of idiopathic low back pain. In: Weinstein JN, Gordon S, editors. Low Back Pain: A Scientific and Clinical Overview. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1996. p. 637-41.
12. Vogt MT, Rubin D, Valentin RS, Palermo L, Donaldson WF 3rd, Nevitt M, et al. Lumbar olisthesis and lower back symptoms in elderly white women. The study of osteoporotic fractures. Spine 1998;23:2640-7.
13. Vogt MT, Rubin DA, Palermo L, Christianson L, Kang JD, Nevitt MC, et al. Lumbar spine listhesis in older African American women. Spine J 2003;3:255-61.
14. Sihvonen T, Lindgren KA, Airaksinen O, Manninen H. Movement disturbances of the lumbar spine and abnormal back muscle. Electromyographic findings in recurrent low back pain. Spine 1997;22:289-95.
15. Kang KK, Shen MS, Zhao W, Lurie JD, Razi AE. Retrolisthesis and lumbar disc herniation: A postoperative assessment of patient function. Spine J 2013;13:367-72.
16. Kim HS, Ju CI, Kim SW, Kang JH. Lying down instability undetected on standing dynamic radiographs. J Korean Neurosurg Soc 2015;58:560-2.
17. Capasso G, Maffulli N, Testa V. Inter and intratester reliability of radiographic measurement of spondlylolisthesis. Act Orthop Belg 1992;58:188-92.
18. White AA 3rd, Panjabi MM. Clinical Biomechanics of the Spine. 2nd ed. Philadelphia, PA: Lippincot Williams and Wilkins; 1990
19. Friberg O. Lumbar instability: A dynamic approach by traction-compression radiography. Spine 1987;12:119-29.
20. Hayes MA, Howard TC, Gruel CR, Kopta JA. Roentgenographic evaluation of lumbar spine flexion–extension in asymptomatic individuals. Spine 1989;14:327-31.
21. Dvorak J, Panjabi MM, Novotny JE, Chang DG, Grob D. Clinical validation of functional flexion-extension roentgenograms of the lumbar spine. Spine 1991;16:943-50.
22. Stokes IA, Frymoyer JW. Segmental motion and instability. Spine 1987;12:688-91.
23. Shaffer WO, Spratt KF, Weinstein J, Lehmann TR, Goel V. 1990 Volvo Award in clinical sciences. The consistency and accuracy of roentgenograms for measuring sagittal translation in the lumbar vertebral motion segment. An experimental model. Spine 1990;15:741-50.


How to Cite this Article: Dave BR, Mayi SC, Krishnan A, Kohli R, Degulmadi D, Rai RR, Dave MB | A Prospective Study to Find Out the Association Between Supine Lying Low Back Pain and Retrolisthesis | Back Bone: The Spine Journal | April-September 2022; 3(1): 42-46. https://doi.org/10.13107/bbj.2022.v03i01.039

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