Presumptive Long Rod Technique (PLRT) for Revision Extension Instrumented Spine Surgery: A Technical Note

Volume 3 | Issue 2 | October 2022-March 2023 | page: 119-124 | Ajay Krishnan, Shivakumar A Bali, Devanand Degulmadi, Shivanand Mayi, Ravi Ranjan, Vatsal Parmar, Pranav Charde, Vikrant Chauhan, Mirant B Dave, Denish Patel, Preety A Krishnan, Bharat R Dave

DOI: https://doi.org/10.13107/bbj.2022.v03i02.050


Authors: Ajay Krishnan [1], Shivakumar A Bali [1], Devanand Degulmadi [1], Shivanand Mayi [1], Ravi Ranjan [1], Vatsal Parmar [1], Pranav Charde [1], Vikrant Chauhan [1], Mirant B Dave [1], Denish Patel [1], Preety A Krishnan [2], Bharat R Dave [1]

[1] Department of Spine Surgery, Stavya Spine Hospital & Research Institute, Mithakhali, Ellisbridge, Ahmedabad, Gujarat, India.
[2] Department of Radiology, Stavya Spine Hospital & Research Institute, Mithakhali, Ellisbridge, Ahmedabad, Gujarat, India.

Address of Correspondence

Dr. Ajay Krishnan,
Spine Surgeon, Department of Spine Surgery, Stavya Spine Hospital & Research Institute, Mithakhali, Ellisbridge, Ahmedabad, Gujarat, India.
E-mail: drajaykrishnan@gmail.com


Abstract


Background: Revision spine surgery needing extension of fixation either require complete exposure of previously operated levels for rod exchange or can be managed by linking the new surgical construct (NSC) to primary surgical construct (PSC) with dominos. Presumptive long rod technique (PLRT) provides additional length of rod for domino placement.
Case report: 80-year male on conservative management developed acute cauda equina syndrome retention due to pre-existing multilevel lumbar stenosis and acute big sequestrated disc prolapse at L12. Emergent surgical intervention in form of L1 to L4 pedicle screw fixation with postero-lateral bone grafting and fragmentectomy was done. Peri-operative period was uneventful. He was started on Teriperatide 20mcg daily with progressive mobilization and physiotherapy. At 4 months of follow-up, he developed L1 osteoporotic fracture with proximal junctional kyphosis (PJK). Patient underwent T12-L1 interbody fusion with extension of fixation to T10 which required complete opening up of previous incision as it was an Indian implant set. A domino of larger foot print couldn’t be accommodated in the space available between L1- L2 screws. Owing to severe osteoporosis and degenerative changes at proximal levels, presumptive oversized rods were inserted with extra lengths of the rods left at proximal ends. This technique is labelled PLRT(presumptive long rod technique) at our institute. At 6 months of follow up, patient developed T10 osteoporotic fracture with PJK and patient was planned for extension of fixation upto T4. Since the extra lengths of rods were available at proximal ends, only the planned operative levels were exposed and it was connected to previous construct using the larger footprint domino. Patient improved clinically and was ambulatory. The patient expired at 18 months due to cardio-respiratory arrest unrelated to the spinal events.
Conclusion: Additional rod lengths intentionally left at adjacent levels during primary surgery where there is anticipation of PJK and adjacent segment disease (ASD) can be a boon when there is need for extension of fixation. These extra lengths of rod can be used to place dominos and connect PSC to NSC without the need for exposure of PSC levels for rod exchange, preventing complications especially in setups with economic constraints.
Keywords: Complex, Adult Spinal Deformity, Adjacent Segment, Junctional Kyphosis, Osteoporosis, Revision, Surgery, Multirod.


References


1. Welke B, Schwarze M, Hurschler C, Nebel D, Bergmann N, Daentzer D. In vitro investigation of two connector types for continuous rod construct to extend lumbar spinal instrumentation. Eur Spine J. 2018 Aug;27(8):1895-1904. doi: 10.1007/s00586-018-5664-3. Epub 2018 Jun 12. PMID: 29948326.
2. Chow DH, Luk KD, Evans JH, Leong JC. Effects of short anterior lumbar interbody fusion on biomechanics of neighboring unfused segments. Spine (Phila Pa 1976). 1996 Mar 1;21(5):549-55. doi: 10.1097/00007632-199603010-00004. PMID: 8852308.
3. Park P, Garton HJ, Gala VC, Hoff JT, McGillicuddy JE. Adjacent segment disease after lumbar or lumbo¬sacral fusion: review of the literature. Spine (Phila Pa 1976) 2004;29:1938-44.
4. Wang MY. Improvement of sagittal balance and lumbar lordosis following less invasive adult spinal deformity surgery with expandable cages and percutaneous instrumentation. J Neurosurg Spine 2013;18:4–12.
5. Eichholz KM, Ryken TC. Complications of revision spinal surgery. Neurosurg Focus 2003;15:E1.
6. Deyo RA, Mirza SK, Martin BI, KreuterW, Goodman DC, Jarvik JG. Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults. JAMA 2010;303: 1259–65.
7. Nasser R, Yadla S, Maltenfort MG, Harrop JS, Anderson DG, Vaccaro AR, et al. Complications in spine surgery. J Neurosurg Spine 2010;13:144–57.
8. Hashimoto K, Aizawa T, Kanno H, Itoi E. Adjacent segment degeneration after fusion spinal surgery-a systematic review. Int Orthop. 2019 Apr;43(4):987-993. doi: 10.1007/s00264-018-4241-z. Epub 2018 Nov 23. PMID: 30470865.
9. Yagi M, Akilah KB, Boachie-Adjei O. Incidence, risk factors and classification of proximal junctional kyphosis: surgical outcomes review of adult idiopathic scoliosis. Spine (Phila Pa 1976) 2011;36:E60e8
10. Ogawa H, Hori H, Oshita H, Akaike A, Koyama Y, Shimizu T, Yamada K, Ishimaru D. Sublaminar wiring stabilization to prevent adjacent segment degeneration after lumbar spinal fusion. Arch Orthop Trauma Surg. 2009 Jul;129(7):873-8. doi: 10.1007/s00402-008-0725-4. Epub 2008 Aug 22. PMID: 18719930.
11. Hassanzadeh H, Gupta S, Jain A, El Dafrawy MH, Skolasky RL, Kebaish KM. Type of Anchor at the Proximal Fusion Level Has a Significant Effect on the Incidence of Proximal Junctional Kyphosis and Outcome in Adults After Long Posterior Spinal Fusion. Spine Deform. 2013 Jul;1(4):299-305. doi: 10.1016/j.jspd.2013.05.008. Epub 2013 Aug 2. PMID: 27927362.
12. Kanayama M, Hashimoto T, Shigenobu K et al (2001) Adjacentsegment morbidity after Graf ligamentoplasty compared with posterolateral lumbar fusion. J Neurosurg 95:5–10
13. Strauss PJ, Novotny JE, Wilder DG et al (1994) Multidirectional stability of the Graf system. Spine 19:965–972
14. Orthofix (2019).Connector system operative technique. https://www.orthofix.com/wp-content/uploads/2019/01/Connector-System-Operative-Technique.pdf
15. Zimmer biomet. Polaris spinal system domino rod connectors surgical technique guide. https://www.zimvie.com/content/dam/zimvie-corporate/en/products/specialties/spine/polaris-deformity-system/0328.1-GLBL-en-REV0318-Polaris-Domino-STG.pdf
16. Tatsumi rl, yoo ju, liu q, hart ra. Mechanical comparison of posterior instrumentation constructs for spinal fixation across the cervicothoracic junction. Spine (phila pa 1976). 2007;32: 1072-1076.
17. Tan QC, Huang JF, Bai H, Liu ZX, Huang XY, Zhao X, Yang Z, Du CF, Lei W, Wu ZX. Effects of Revision Rod Position on Spinal Construct Stability in Lumbar Revision Surgery: A Finite Element Study. Front Bioeng Biotechnol. 2022 Jan 5;9:799727. doi: 10.3389/fbioe.2021.799727. PMID: 35071208; PMCID: PMC8766337.
18. Chechik O, Fishkin M, Wientroub S, Ovadia D. A new pelvic rod system for the surgical correction and fixation of pelvic obliquity in pediatric neuromuscular scoliosis. J Child Orthop. 2011 Feb;5(1):41-8. doi: 10.1007/s11832-010-0318-y. Epub 2010 Dec 14. PMID: 22295048; PMCID: PMC3024490.
19. Senatus P, Chinthakunta SR, Vazifeh P, Khalil S. Biomechanical evaluation of a novel posterior integrated clamp that attaches to an existing posterior instrumentation for use in thoracolumbar revision. Asian Spine J. 2013 Mar;7(1):1-7. doi: 10.4184/asj.2013.7.1.1. Epub 2013 Mar 6. PMID: 23508231; PMCID: PMC3596578
20. Hohn EA, Chu B, Martin A, Yu E, Telles C, Leasure J, Lynch TL, Kondrashov D. The Pedicles Are Not the Densest Regions of the Lumbar Vertebrae: Implications for Bone Quality Assessment and Surgical Treatment Strategy. Global Spine J. 2017 Sep;7(6):567-571. doi: 10.1177/2192568217694141. Epub 2017 Apr 11. PMID: 28894687; PMCID: PMC5582706.
21. El Dafrawy MH, Adogwa O, Wegner AM et al (2020) Comprehensive classification system for multirod constructs across three column osteotomies: a reliability study. J Neurosurg Spine. https://doi. org/ 10. 3171/ 2020.6. SPINE 20678
22. Krishnan A, Raj A, Meena U, Degulmadi D, Rai RR, Mayi S, Dave M, Dave BR. RCC (reinforced criss-cross construct): an easy and effective multi-rod thoraco-lumbar posterior reconstruction technique. Spine Deform. 2022 Apr 9. doi: 10.1007/s43390-022-00504-w. Epub ahead of print. PMID: 35397069.
23. Rathjen K, Wood M, McClung A, Vest Z. Clinical and radiographic results after implant removal in idio¬pathic scoliosis. Spine (Phila Pa 1976) 2007;32:2184- 8.
24. Pattanayak S. Expenditure Control: Key Features, Stages, and Actors.IMF 2016 March. https://www.imf.org/external/pubs/ft/tnm/2016/tnm1602a.pdf


How to Cite this Article: Krishnan A, Bali SA, Degulmadi D, Mayi S, Ranjan R, Parmar V, Charde P, Chauhan V, Dave MB, Patel D, Krishnan PA, Dave BR | Presumptive Long Rod Technique (PLRT) for Revision Extension Instrumented Surgery: A Technical Note | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 119-124. https://doi.org/10.13107/bbj.2022.v03i02.050

(Abstract Text HTML)      (Download PDF)


.

Hirayama Disease: A Rare Case Report and Literature Review

Volume 3 | Issue 2 | October 2022-March 2023 | page: 109-112 | Sharvin K Sheth, Amit C Jhala, Jay V Shah

DOI: https://doi.org/10.13107/bbj.2022.v03i02.048


Authors: Sharvin K Sheth [1], Amit C Jhala [1], Jay V Shah [2]

[1] Department of Spine Surgery, Chirayu Orthopaedic and Spine Hospital, Ahmedabad, Gujarat, India.
[2] Department of Radiology, Medimax Advance Radio Imaging, Ahmedabad, Gujarat, India.

Address of Correspondence

Dr. Amit C Jhala,
Consultant Spine Surgeon and Chief of Department of Spine Surgery, Chirayu Orthopaedic and Spine Hospital, Ahmedabad, Gujarat, India.
E-mail: acjhala@gmail.com


Abstract


Hirayama disease is a rare neurological condition and is characterized by a sporadic juvenile muscular atrophy of distal upper extremity in young males. The disease is more prevalent in Japan and other Asian countries, though a few cases have been reported in Western countries as well. It manifests as a self-limiting, gradually progressive atrophic weakness of forearm and hand. The anterior displacement of posterior dura during neck flexion leading to cervical cord atrophy has been hypothesized. We discuss a case of a 21-year-old male patient with progressive distal upper extremity weakness, diagnosed with Hirayama disease, and literature review for the same.
Keywords: Hirayama Disease, Juvenile muscular atrophy, Monomelic amyotrophy


References


1. Hirayama K, Tsubaki T, Toyokura Y, Okinaka S. Juvenile muscular atrophy of unilateral upper extremity. Neurology. 1963;13:373-80.
2. Sobue I, Saito M, Iida M, Ando K. Juvenile type of distal and segmental muscular atrophy of upper extremities. Ann Neurol. 1978;3:429–32.
3. Gourie-Devi M, Suresh TG, Shankar SK. Monomelic amyotrophy. Arch Neurol. 1984;4:388–94.
4. Pilgaard S. Unilateral juvenile muscular atrophy of upper limbs. Acta Orthop Scand 1968;39:327-31.
5. Compernolle T. A case of juvenile muscular atrophy confined to one upper limb. Eur Neurol. 1973;10(4):237-42.
6. Oryema J, Ashby P, Spiegel S. Monomelic atrophy. Can J Neurol Sci. 1990;17:124–30.
7. Donofrio PD. Monomelic amyotrophy. Muscle Nerve. 1994;17:1129–34.
8. Hirayama K. Juvenile muscular atrophy of distal upper extremity (Hirayama disease). Intern Med. 2000;39:283–90.
9. Hirayama K, Tokumaru Y. Cervical dural sac and spinal cord in juvenile muscular atrophy of distal upper extremity. Neurology. 2000;54:1922–6.
10. Ojha R, Shahi S, Nepal G, Shakya A, Gajurel BP, Karn R, Rajbhandari R, Gautam N. The diagnostic quandary of magnetic resonance imaging-negative Hirayama disease: a case report. J Med Case Rep. 2020 Aug 21;14(1):133.
11. S. D. Yoo, H.-S. Kim, D. H. Yun et al., “Monomelic amyotrophy (Hirayama disease) with upper motor neuron signs: a case report,” Annals of Rehabilitation Medicine (2015);39(1):122-127.
12. Anuradha S, Fanai V. Hirayama Disease: A Rare Disease with Unusual Features. Case Rep Neurol Med. 2016;2016:5839761.
13. K. M. Hassan, H. Sahni, and A. Jha, “Clinical and radiological profile of Hirayama disease: a flexion myelopathy due to tight cervical dural canal amenable to collar therapy,” Annals of Indian Academy of Neurology (2012); 15(2): 106-112.
14. K. Tashiro, S. Kikuchi, Y. Itoyama et al., “Nationwide survey of juvenile muscular atrophy of distal upper extremity (Hirayama disease) in Japan,” Amyotrophic Lateral Sclerosis (2006); 7(1):38-45.
15. Shruti Thakur, R.G. Sood, Anupam Jhobta, Dinesh Sharma, Sushma Makhaik, Neeti Aggarwal, Charu S. Thakur. “Hirayama disease in unilateral and bilateral forms-3 case reports”. The Egyptian Journal of Radiology and Nuclear Medicine (2013); 44(2):291-295.
16. Hirayama K, Tomonaga M, Kitano K, Yamada T, Kojima S, Arai K. Focal cervical poliopathy causing juvenile muscular atrophy of distal upper extremity: a pathological study. J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):285-90.
17. Virmani V, Mohan PK. Non-familial, spinal segmental muscular atrophy in juvenile and young subjects. Acta Neurol Scand. 1985;72:336–40.
18. Tanaka M, Ishizu T, Ochi H, et al. Intrathecal upregulation of IFN- gamma and MIP-1beta in juvenile muscular atrophy of the distal upper extremity. J Neurol Sci 2008;275:74 –77.
19. Kikuchi S, Tashiro K, Kitagawa M, Iwasaki Y, Abe H. A mechanism of juvenile muscular atrophy localized in the hand and forearm (Hirayama’s disease): flexion myelopathy with tight dural canal in flexion (in Japanese). Clin Neurol (Tokyo). 1987 Apr;27(4):412-9.
20. Narayana Gowda BS, Mohan Kumar J, Basim PK. Hirayama’s Disease – A Rare Case Report with Review of Literature. J Orthop Case Rep. 2013 Jul-Sep;3(3):11-4.
21. Kato Y, Kataoka H, Ichihara K, Imajo Y, Kojima T, Kawano S, Hamanaka D, Yaji K, Taguchi T. Biomechanical study of cervical flexion myelopathy using a three-dimensional finite element method. J Neurosurg Spine. 2008 May;8(5):436-41.
22. Lai V, Wong YC, Poon WL, Yuen MK, Fu YP, Wong OW. Forward shifting of posterior dural sac during flexion cervical magnetic resonance imaging in Hirayama disease: an initial study on normal subjects compared to patients with Hirayama disease. Eur J Radiol. 2011 Dec;80(3):724-8.
23. Boruah DK, Prakash A, Gogoi BB, Yadav RR, Dhingani DD, Sarma B. The Importance of Flexion MRI in Hirayama Disease with Special Reference to Laminodural Space Measurements. AJNR Am J Neuroradiol. 2018 May;39(5):974-980.
24. Xu H, Shao M, Zhang F, Nie C, Wang H, Zhu W, Xia X, Ma X, Lu F, Jiang J. Snake-Eyes Appearance on MRI Occurs during the Late Stage of Hirayama Disease and Indicates Poor Prognosis. Biomed Res Int. 2019 Jan 13;2019:9830243.
25. Mizuno J, Nakagawa H, Inoue T, Hashizume Y. Clinicopathological study of “snake-eye appearance” in compressive myelopathy of the cervical spinal cord. J Neurosurg. 2003 Sep;99(2 Suppl):162-8.
26. Al-Hashel JY, Abdelnabi EA, Ibrahim Ismail I. Monomelic Amyotrophy (Hirayama Disease): A Rare Case Report and Literature Review. Case Rep Neurol. 2020 Sep 17;12(3):291-298.
27. Jin X, Jiang JY, Lu FZ, Xia XL, Wang LX, Zheng CJ. Electrophysiological differences between Hirayama disease, amyotrophic lateral sclerosis and cervical spondylotic amyotrophy. BMC Musculoskelet Disord. 2014 Oct 16;15:349.
28. MARIE, P., and FOIX, c.: L’atrophie isolhe non pro- gressive des petits muscles de la main (Tephromala- cie antCieure). Nouv. iconogr. de la SalpbriBre 25: 353 and 427, 1912.


How to Cite this Article: Sheth SK, Jhala AC , Shah JV |  Hirayama Disease: A Rare Case Report and Literature Review | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 109-112. https://doi.org/10.13107/bbj.2022.v03i02.048

(Abstract Text HTML)      (Download PDF)


.

New Development and Progression of Ossification of the Posterior Longitudinal Ligament (OPLL) after Cervical Disc Arthroplasty: A Case Report

Volume 3 | Issue 2 | October 2022-March 2023 | page: 47-50 | Jong-Beom Park

DOI: https://doi.org/10.13107/bbj.2022.v03i02.040


Authors: Jong-Beom Park [1]

[1] Department of Orthopaedic Surgery, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Address of Correspondence

Dr. Jong-Beom Park,
Department of Orthopaedic Surgery, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
E-mail: spinepjb@gmail.com


Abstract


Purpose: To report an extremely rare case of new development and progression of ossification of posterior longitudinal ligament (OPLL) after cervical disc arthroplasty (CDA).
Background: To our knowledge, new development and progression of ossification of OPLL after CDA have not been reported.
Methods: A 44-year-old female with cervical disc herniation at C5-6 presented with radiculopathy. The patient had no evidence of preexisting OPLL on plain radiographs and magnetic resonance imaging. She underwent CDR at C5-6 and her symptoms were significantly improved after surgery.
Results: New development of OPLL at C5-7-T1 was identified for the first time at 6 years after CDA at C5-6, and progression of OPLL was observed at 3 & 13 years’ follow-up. Due to new development and progression of OPLL, there was no segmental motion at C5-6 with CDA. The patient continued to follow up without further surgery because there was no deterioration in clinical symptoms.
Conclusion: Our study demonstrated an extremely rare case of new development and progression of OPLL after CDA with a long term follow-up. Our case suggests potential clues for discovering the complex pathological mechanism of OPLL.
Keywords: Ossification of the posterior longitudinal ligament, New development, Progression, Cervical disc arthroplasty


References


1. Boody BS, Lendner M, Vaccaro AR. Ossification of the posterior longitudinal ligament in the cervical spine: a review. Int Orthop 2019;43:797-805.
2. Saetia K, Cho D, Lee S, et al. Ossification of the posterior longitudinal ligament: a review. Neurosurg Focus 2011;30:E1.
3. Inamasu J, Guiot BH, Sachs DC. Ossification of the posterior longitudinal ligament: an update on its biology, epidemiology, and natural history. Neurosurgery 2006;58:1027-1039.
4. Fargen KM, Cox JB, Hoh DJ. Does ossification of the posterior longitudinal ligament progress after laminoplasty? Radiographic and clinical evidence of ossification of the posterior longitudinal ligament lesion growth and the risk factors for late neurologic deterioration. J Neurosurg Spine 2012;17:512-524.
5. Kato Y, Iwasaki M, Fuji T, et al. Long-term follow-up results of laminectomy for cervical myelopathy caused by ossification of the posterior longitudinal ligament. J Neurosurg 1998;89:217-223.
6. Nam DC, Lee HJ, Lee CJ, et al. Molecular pathophysiology of ossification of the posterior longitudinal ligament (OPLL). Biomol Ther (Seoul) 2019;27:342-348.
7. Chen S, Zhu H, Wang G, et al. Combined use of leptin and mechanical stress has osteogenic effects on ossification of the posterior longitudinal ligament. Eur Spine J 2018;27:1757-1766.
8. Shi L, Miao J, Chen D, et al. Endoplasmic reticulum stress regulates mechanical stress-induced ossification of posterior longitudinal ligament. Eur Spine J 2019;28:2249-2256.
9. Rustagi T, Alonso F, Schmidt C, et al. Rapid progression of ossification of the posterior longitudinal ligament after anterior cervical discectomy and fusion. World Neurosurg 2018;110:11-16.
10. Murakami M, Seichi A, Chikuda H, et al. Long-term follow-up of the progression of ossification of the posterior longitudinal ligament. J Neurosurg Spine 2010;12:577-579.
11. Ham JS, Kim JH, Yoon JH, et al. Progression of ossification of the posterior longitudinal ligament after cervical total disc replacement. Korean J Neurotraum. 2019;15:135-142.
12. Wang L, Jiang Y, Li M, et al. Postoperative progression of cervical ossification of posterior longitudinal ligament: a systematic review. World Neurosurg 2019;126:593-600.
13. Park S, Lee DH, Ahn J, et al. How does ossification of posterior longitudinal ligament progress in conservatively managed patients? Spine (Phila Pa 1976) 2019;45:234-243.
14. Shin J, Choi JY, Kim YW, et al. Quantification of risk factors for cervical ossification of the posterior longitudinal ligament in Korean populations: a nationwide population-based case-control study. Spine (Phila Pa 1976) 2019;44:E957-E964.
15. Vaziri S, Lockney DT, Dru AB, et al. Does Ossification of the Posterior Longitudinal Ligament Progress After Fusion? Neurospine 2019;16:483-491.
16. Lee JJ, Shin DA, Yi S, et al. Effect of posterior instrumented fusion on three-dimensional volumetric growth of cervical ossification of the posterior longitudinal ligament: a multiple regression analysis. Spine J 2018;18:1779-1786.
17. Sekijima Y, Yoshida T, Ikeda S. Are there differences in the progression of ossification of the posterior longitudinal ligament following laminoplasty versus fusion? a meta-analysis. Spine (Phila Pa 1976) 2017;42:887-894.
18. Kang MS, Kim KH, Park JY, et al. Progression of Cervical Ossification of Posterior Longitudinal Ligament After Laminoplasty or Laminectomy With Posterior Fixation. Clin Spine Surg 2019;32:363-368.
19. Tokuhashi Y, Ajiro Y, Umezawa N. A patient with two re-surgeries for delayed myelopathy due to progression of ossification of the posterior longitudinal ligaments after cervical laminoplasty. Spine (Phila Pa 1976) 2009;34:E101-E105.
20. Chiba K, Yamamoto I, Hirabayashi H, et al. Multicenter study investigating the postoperative progression of ossification of the posterior longitudinal ligament in the cervical spine: a new computer-assisted measurement. J Neurosurg Spine 2005;3:17-23.
21. Katsumi K, Izumi T, Ito T, et al. Posterior instrumented fusion suppresses the progression of ossification of the posterior longitudinal ligament: a comparison of laminoplasty with and without instrumented fusion by three-dimensional analysis. Eur Spine J 2016;25:1634-1640.
22. Lee SE, Jahng TA, Kim HJ. Surgical outcomes of the ossification of the posterior longitudinal ligament according to the involvement of the C2 segment. World Neurosurg 2016;90:51-57.
23. Takatsu T, Ishida Y, Suzuki K, et al. Radiological study of cervical ossification of the posterior longitudinal ligament. J Spinal Disord 1999;12:271-273.
24. Hui N, Phan K, Cheng HMK, et al. Complications of cervical total disc replacement and their association with heterotopic ossification: a systemic review and meta-analysis. Eur Spine J. 2020;2688-2700.
25. Wang X, Liu H, Meng Y, et al. Effect of disc height and degree of distraction on heterotopic ossification after cervical disc replacement. World Neurosurg. 2021;145:e100-e107.
26. Yonenobu K. Is surgery indicated for asymptomatic or mildly myelopathic patients with significant ossification of the posterior longitudinal ligament? Spine (Phila Pa 1976). 2012;37:E315-E317.
27. Iwasaki M, Kawaguchi Y, Kimura T, et al. Long-term results of expansive laminoplasty for ossification of the posterior longitudinal ligament of the cervical spine: more than 10 years follow up. J Neurosurg. 2002;96:180-189.


How to Cite this Article: Park JB | New Development and Progression of Ossification of the Posterior Longitudinal Ligament (OPLL) after Cervical Disc Arthroplasty | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 47-50. https://doi.org/10.13107/bbj.2022.v03i02.040

(Abstract Text HTML)      (Download PDF)


.

Post-Discectomy Pyogenic Lumbar Discitis- A Literature Review

Volume 3 | Issue 2 | October 2022-March 2023 | page: 55-64 | Udit D. Patel1, Hitesh N. Modi1

DOI: https://doi.org/10.13107/bbj.2022.v03i02.042


Authors: Udit D. Patel [1], Hitesh N. Modi [1]

[1] Department of Spine Surgery, Zydus Hospitals and Healthcare Research Private Limited, Zydus hospital road, Thaltej, Ahmedabad, Gujarat, India 380054.

Address of Correspondence

Dr. Udit D. Patel
Department of Spine Surgery, Zydus Hospitals and Healthcare Research Private Limited, Zydus hospital road, Thaltej, Ahmedabad, Gujarat, India 380054.
E-mail: uditpatel27@gmail.com


Abstract


Introduction: Post-disctectomy pyogenic lumbar discitis is not common condition in contrast to postoperative wound infection but its presentation is typically non-specific, which can lead to delay in diagnosis and its treatment. In this condition, patients present with low back pain after symptoms free interval. The diagnosis can be established with symptoms, examination, laboratory studies and radiological investigations.
Purpose: The aim of this literature review is to evaluate available articles about post- discectomy lumbar spondylodiscitis. we analyse the incidence, risk factors, causative organisms, diagnosis modalities (including clinical features, blood and radiological investigations), management strategies (conservative and surgical) and prevention for postoperative lumbar spondylodiscitis in the published literature.
Material and methods: We have reviewed literature articles available on topic of post-discectomy lumbar discitis in PubMed, MEDLINE and Google scholar only in English language; and have been published from the year 2000 onwards.
Results: This incidence rate of post-operative discitis is 0.94%. The age range was 38-56 years with a mean age of 45.18±4.17 years. Mean interval between discectomy and establishment of diagnosis was 2-8 weeks. Of all the patients included 61.93% were males and 38.07% were females. The most common organism isolated is staph. aureus (including methicillin sensitive and resistant staph. aureus). Majority of patients were initially treated conservatively. The surgical treatment in patients who fail to respond to conservative management has been demonstrated. Our study showed 40.1% excellent results, 56% good result and 3.9% fair and poor result at final follow up.
Conclusion: Although the incidence of post-operative lumbar discitis is rare, it’s associated with morbidity and mortality. The true challenge of post-operative discitis is to diagnose the condition timely. Majority of patients can be treated conservatively and operative management is rarely necessary in the patients with failed conservative treatment.
Keywords:  Lumbar discectomy, Postoperative pyogenic discitis, Literature review, Treatment


References


1. Ramirez, L.F. and R. Thisted, Complications and demographic characteristics of patients undergoing lumbar discectomy in community hospitals. Neurosurgery, 1989. 25(2): p. 226-30; discussion 230-1.
2. Turnbull, F., Postoperative inflammatory disease of lumbar discs. J Neurosurg, 1953. 10(5): p. 469-73.
3. Jimenez-Mejias, M.E., et al., Postoperative spondylodiskitis: etiology, clinical findings, prognosis, and comparison with nonoperative pyogenic spondylodiskitis. Clin Infect Dis, 1999. 29(2): p. 339-45.
4. Jain, M., et al., Postoperative Lumbar Pyogenic Spondylodiscitis: An Institutional Review. J Neurosci Rural Pract, 2019. 10(3): p. 511-518.
5. Adam, D., T. Papacocea, I. Hornea and R. Croitoru, Postoperative spondylodiscitis. A review of 24 consecutive patients. Chirurgia (Bucur), 2014. 109(1): p. 90-4.
6. Eshra, M.A., Experience in the management of post-operative spinal infection. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2019. 55(1): p. 9.
7. Park, M.K., R.A. Myers and L. Marzella, Oxygen tensions and infections: modulation of microbial growth, activity of antimicrobial agents, and immunologic responses. Clin Infect Dis, 1992. 14(3): p. 720-40.
8. Srinivas, B., D. Sekhar, G. Penchalayya and K. Murthy, Post-operative discitis- a review of 10 patients in a tertiary care neurosurgical unit. J Dental Med Sci., 2016. 15(7): p. 1-4.
9. Chang, C.W., et al., Transforaminal Interbody Debridement and Fusion to Manage Postdiscectomy Discitis in Lumbar Spine. World Neurosurg, 2019. 121: p. e755-e760.
10. Kutlay, M., et al., Antibiotic and hyperbaric oxygen therapy in the management of post-operative discitis. Undersea Hyperb Med, 2008. 35(6): p. 427-40.
11. Kaliaperumal, C., D. Kuechler, G. Kaar, C. Marks and M. O’Sullivan, Does surgical technique affect the incidence of spondylodiscitis post-lumbar microdiscectomy? A retrospective analysis of 3063 patients. Spine (Phila Pa 1976), 2012. 38(4): p. 364-7.
12. Bavinzski, G., et al., Microsurgical management of postoperative disc space infection. Neurosurg Rev, 2003. 26(2): p. 102-7.
13. Diren, F., H. Can, M. Onal and A. Kircelli, The rate of spondylodiscitis in the patients with lumbar discectomy using single dose prophylactic antibiotics. J Academic Res in Med., 2019. 9(3).
14. Kucuk, A., et al., Surgical Strategies for Spondylodiscitis due to Lumbar Disc Surgery. Turk Neurosurg, 2017. 27(1): p. 95-98.
15. Santhanam, R. and K. Lakshmi, A Retrospective Analysis of the Management of Postoperative Discitis: A Single Institutional Experience. Asian Spine J, 2015. 9(4): p. 559-64.
16. Ahn, Y. and S.H. Lee, Postoperative spondylodiscitis following transforaminal percutaneous endoscopic lumbar discectomy: clinical characteristics and preventive strategies. Br J Neurosurg, 2012. 26(4): p. 482-6.
17. Singh, D.K., N. Singh, P.K. Das and D. Malviya, Management of Postoperative Discitis: A Review of 31 Patients. Asian J Neurosurg, 2018. 13(3): p. 703-706.
18. Shah, R., A. Garud, P. Vala and V. Sharma, Early onset postdiscectomy spinal tuberculosis: an uncommon complication. Asian J Orthopedic Research, 2019. March(7): p. 1-4.
19. Zink, P.M., A.M. Frank and A.E. Trappe, Prophylaxis of postoperative lumbar spondylodiscitis. Neurosurg Rev, 1989. 12(4): p. 297-303.
20. Weinstein, M.A., J.P. McCabe and F.P. Cammisa, Jr., Postoperative spinal wound infection: a review of 2,391 consecutive index procedures. J Spinal Disord, 2000. 13(5): p. 422-6.
21. Chaudhary, S.B., M.J. Vives, S.K. Basra and M.F. Reiter, Postoperative spinal wound infections and postprocedural diskitis. J Spinal Cord Med, 2007. 30(5): p. 441-51.
22. Koutsoumbelis, S., et al., Risk factors for postoperative infection following posterior lumbar instrumented arthrodesis. J Bone Joint Surg Am, 2011. 93(17): p. 1627-33.
23. Hamdan, T.A., Postoperative disc space infection after discectomy: a report on thirty-five patients. Int Orthop, 2012. 36(2): p. 445-50.
24. Moon, M.S., et al., Pyogenic discitis following discectomy. J Orthop Surg (Hong Kong), 2012. 20(1): p. 11-7.
25. Katonis, P., M. Tzermiadianos, P. Papagelopoulos and A. Hadjipavlou, Postoperative infections of the thoracic and lumbar spine: a review of 18 cases. Clin Orthop Relat Res, 2007. 454: p. 114-9.
26. Sheha, A., Surgical management of post-discectomy spondylodiscitis with transforaminal lumbar interbody fusion (TLIF) and posterior instrumentation. Life Sci J., 2011. 8(4): p. 140-42.
27. Ahsan, K., et al., Conservative versus operative management of postoperative lumbar discitis. J Craniovertebr Junction Spine, 2020. 11(3): p. 198-209.
28. Salgotra, B., S. Attry, D. Patel and K. Sansiya, Open transforaminal lumbar interbody fusion (TLIF) for post-discectomy spondylodiscitis: Our experiece. Indian J Neuroscience, 2018. 4(3): p. 144-9.
29. Chew, F.S. and M.J. Kline, Diagnostic yield of CT-guided percutaneous aspiration procedures in suspected spontaneous infectious diskitis. Radiology, 2001. 218(1): p. 211-4.
30. Rao, P.J., et al., Histological analysis of surgical samples and a proposed scoring system for infections in intervertebral discs. J Clin Neurosci, 2016. 30: p. 115-119.
31. Zhang, T., et al., One-stage posterior debridement and fusion combined with irrigation and drainage for the treatment of postoperative lumbar spondylodiscitis. Acta Orthop Traumatol Turc, 2018. 52(4): p. 277-282.
32. Harris, A.E., C. Hennicke, K. Byers and W.C. Welch, Postoperative discitis due to Propionibacterium acnes: a case report and review of the literature. Surg Neurol, 2005. 63(6): p. 538-41; discussion 541.
33. Van Goethem, J.W., et al., The value of MRI in the diagnosis of postoperative spondylodiscitis. Neuroradiology, 2000. 42(8): p. 580-5.
34. Meyer, B., K. Schaller, V. Rohde and W. Hassler, The C-reactive protein for detection of early infections after lumbar microdiscectomy. Acta Neurochir (Wien), 1995. 136(3-4): p. 145-50.
35. Barrey, C., et al., The follow-up of patients with postoperative infection of the spine. Eur J Orthop Surg Traumatol, 2013. 23 Suppl 1: p. S29-34.
36. Kang, B.U., S.H. Lee, Y. Ahn, W.C. Choi and Y.G. Choi, Surgical site infection in spinal surgery: detection and management based on serial C-reactive protein measurements. J Neurosurg Spine, 2010. 13(2): p. 158-64.
37. Enoch, D.A., et al., Value of CT-guided biopsy in the diagnosis of septic discitis. J Clin Pathol, 2008. 61(6): p. 750-3.
38. Yang, S.C., T.S. Fu, L.H. Chen, W.J. Chen and Y.K. Tu, Identifying pathogens of spondylodiscitis: percutaneous endoscopy or CT-guided biopsy. Clin Orthop Relat Res, 2008. 466(12): p. 3086-92.
39. Basu, S., J.D. Ghosh, F.H. Malik and A. Tikoo, Postoperative discitis following single-level lumbar discectomy: Our experience of 17 cases. Indian J Orthop, 2012. 46(4): p. 427-33.
40. Luzzati, R., et al., Diagnosis, management and outcome of clinically- suspected spinal infection. J Infect, 2009. 58(4): p. 259-65.
41. Wang, X., H. Tao, Y. Zhu, X. Lu and X. Hu, Management of Postoperative Spondylodiscitis with and without Internal Fixation. Turk Neurosurg, 2015. 25(4): p. 513-8.
42. Dall, B.E., D.E. Rowe, W.G. Odette and D.H. Batts, Postoperative discitis. Diagnosis and management. Clin Orthop Relat Res, 1987(224): p. 138-46.
43. Silber, J.S., D.G. Anderson, A.R. Vaccaro, P.A. Anderson and P. McCormick, Management of postprocedural discitis. Spine J, 2002. 2(4): p. 279-87.
44. Mann, S., M. Schutze, S. Sola and J. Piek, Nonspecific pyogenic spondylodiscitis: clinical manifestations, surgical treatment, and outcome in 24 patients. Neurosurg Focus, 2004. 17(6): p. E3.
45. McHenry, M.C., K.A. Easley and G.A. Locker, Vertebral osteomyelitis: long-term outcome for 253 patients from 7 Cleveland-area hospitals. Clin Infect Dis, 2002. 34(10): p. 1342-50.
46. Kutlay, M., A. Colak, S. Yildiz, N. Demircan and O.N. Akin, Stereotactic aspiration and antibiotic treatment combined with hyperbaric oxygen therapy in the management of bacterial brain abscesses. Neurosurgery, 2008. 62 Suppl 2: p. 540-6.
47. Matsui, H., N. Hirano and Y. Sakaguchi, Vertebral osteomyelitis: an analysis of 38 surgically treated cases. Eur Spine J, 1998. 7(1): p. 50-4.
48. Li, J., D. Yan, L. Duan, Z. Zhang and H. Zhu, Percutaneous discectomy and drainage for postoperative intervertebral discitis. Arch Orthop Trauma Surg, 2011. 131(2): p. 173-8.
49. Fountain, S.S., A single-stage combined surgical approach for vertebral resections. J Bone Joint Surg Am, 1979. 61(7): p. 1011-7.
50. Liljenqvist, U., et al., Titanium cages in the surgical treatment of severe vertebral osteomyelitis. Eur Spine J, 2003. 12(6): p. 606-12.
51. Przybylski, G.J. and A.D. Sharan, Single-stage autogenous bone grafting and internal fixation in the surgical management of pyogenic discitis and vertebral osteomyelitis. J Neurosurg, 2001. 94(1 Suppl): p. 1-7.
52. Gerometta, A., F. Bittan and J.C. Rodriguez Olaverri, Postoperative spondilodiscitis. Int Orthop, 2012. 36(2): p. 433-8.
53. Lang, R., Y. Folman, M. Ravid, T. Bental and R. Gepstein, Penetration of ceftriaxone into the intervertebral disc. J Bone Joint Surg Am, 1994. 76(5): p. 689-91.
54. Tai, C.C., et al., Antibiotic prophylaxis in surgery of the intervertebral disc. A comparison between gentamicin and cefuroxime. J Bone Joint Surg Br, 2002. 84(7): p. 1036-9.


How to Cite this Article: Patel UD, Modi HN | Post-Discectomy Pyogenic Lumbar Discitis- A Literature Review | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 55-64. https://doi.org/10.13107/bbj.2022.v03i02.042

(Abstract Text HTML)      (Download PDF)


.

Fusion with stabilization for the treatment of post-operative Lumbar spondylodiscitis: Our experience

Volume 3 | Issue 2 | October 2022-March 2023 | page: 84-89 | Md. Anowarul Islam, Wayez Mahbub, Suvradev Saha, Afia Ibnat Islam

DOI: https://doi.org/10.13107/bbj.2022.v03i02.045


Authors: Md. Anowarul Islam [1], Wayez Mahbub [1], Suvradev Saha [1], Afia Ibnat Islam [2]

[1] Department of Spine Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
[2] Department of Spine Surgery, Holy Family & Red Crecent Medical College & Hospital, Dhaka, Bangladesh.

Address of Correspondence
Dr. Md. Anowarul Islam ,
Professor of Spine Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
E-mail: maislam.spine@gmail.com


Abstract


Objective: To analyse the outcome of fusion with stabilization for the treatment of postoperative lumbar spondylodiscitis.
Background: Post-operative spondylodiscitis is a dreadful complication following disc surgery. Treatment option is either conservative or operative, but till date, there are no universally accepted treatment protocol. Many studies suggest early surgical intervention provides good outcome. Different mode of surgical interventions can be applied for its treatment like debridement only, debridement followed by fusion with or without stabilization. In this study, we treat all of our patients having post-operative spondylodiscitis by fusion with stabilization.
Materials & methods: Retrospectively we reviewed 20 cases from January 2016 to July 2021 in Bangabandhu Sheikh Mujib Medical University and other private hospitals of Dhaka, Bangladesh. Post-operative spondylodiscitis was diagnosed according to history, specific clinical findings, laboratory and radiographic investigations. Surgery was the treatment of choice in our cases. Pre and postoperative evaluations were done by the Visual Analog scale (VAS), Nurick score for neurological outcome, Modified Kirkaldy–Willis criteria for functional outcome and Modified Lee’s criteria for fusion assessment.
Results: Total number of patients was 20. Mean age was 48 years (range 22-83). Average follow-up period was 12 months. The period between the surgery and the onset of symptoms was 14 to 28 days. Pre-operative VAS score was 8.10±1.7 and post-operatively was 1.7±0.6 at the last follow-up (P< 0.001). Pre & post-operative Nurick score was 2.7 & 0.7. Functional outcome was assessed in our study by Modified Kirkaldy-Willis criteria which shows 90% patient have satisfactory outcome while 10% have unsatisfactory outcome. Modified Lee’s criteria show definitive fusion in 55%, probable fusion in 35% & possible pseudarthrosis in 10% cases.
Conclusion: Early diagnosis and proper management are the keys to successful outcome of postoperative spondylodiscitis. Surgical management in the form of fusion and transpedicular fixation can give excellent results.
Keywords: Sondylodiscitis, Fusion, Stabilizationp


References


1) Guerado E, Cerván AM. Surgical treatment of spondylodiscitis. An update. International orthopaedics. 2012 Feb;36(2):413-20.
2) Basu S, Ghosh JD, Malik FH, Tikoo A. Postoperative discitis following single-level lumbar discectomy: Our experience of 17 cases. Indian Journal of Orthopaedics. 2012 Aug;46(4):427-33.
3) Jiménez-Mejías ME, de Dios Colmenero J, Sánchez-Lora FJ, Palomino-Nicás J, Reguera JM, García de la Heras J, García-Ordoñez MA, Pachón J. Postoperative spondylodiskitis: etiology, clinical findings, prognosis, and comparison with nonoperative pyogenic spondylodiskitis. Clinical Infectious Diseases. 1999 Jul 15;29(2):339-45.
4) Gerometta A, Bittan F, Rodriguez Olaverri JC. Postoperative spondilodiscitis. International orthopaedics. 2012 Feb;36(2):433-8.
5) Stošić-Opinćal TL, Perić V, Grujičić DM, Gavrilović S, Golubičić IV. The role of magnetic resonance imaging in the diagnosis of postoperative spondylodiscitis. Vojnosanitetski pregled. 2004;61(5):479-83.
6) Puranen J, Mäkelä J, Lähde S. Postoperative intervertebral discitis. Acta Orthopaedica Scandinavica. 1984 Jan 1;55(4):461-5.
7) WaNg X, Tao H, ZHu Y, Lu X, Hu X. Management of postoperative spondylodiscitis with and without internal fixation. Turk Neurosurg. 2015 Jan 1;25(4):513-8.
8) Osti OL, Fraser RD, Vernon-Roberts B. Discitis after discography. The role of prophylactic antibiotics. The Journal of Bone and Joint Surgery. British volume. 1990 Mar;72(2):271-4.
9) Tronnier V, Schneider R, Kunz U, Albert F, Oldenkott P. Postoperative spondylodiscitis: results of a prospective study about the aetiology of spondylodiscitis after operation for lumbar disc herniation. Acta neurochirurgica. 1992 Sep;117(3):149-52.
10) Ahmad M, Yasin M. LUMBER DISCITIS: PREVALENCE AND MANAGEMENT AFTER LUMBER DISC SURGERY. The Professional Medical Journal. 2010 Dec 10;17(04):628-32.
11) Lee JS, Moon KP, Kim SJ, Suh KT. Posterior lumbar interbody fusion and posterior instrumentation in the surgical management of lumbar tuberculous spondylitis. The Journal of Bone and Joint Surgery. British volume. 2007 Feb;89(2):210-4.
12) Moon MS, Kim SS, Lee BJ, Moon JL, Sihn JC, Moon SI. Pyogenic discitis following discectomy. Journal of Orthopaedic Surgery. 2012 Apr;20(1):11-7.
13) Blizzard DJ, Hills CP, Isaacs RE, Brown CR. Extreme lateral interbody fusion with posterior instrumentation for spondylodiscitis. Journal of Clinical Neuroscience. 2015 Nov 1;22(11):1758-61
14) Devkota P, Krishnakumar R, Kumar JR. Surgical management of pyogenic discitis of lumbar region. Asian Spine Journal. 2014 Apr;8(2):177.
15) Sapico FL, Montgomerie JZ. Pyogenic vertebral osteomyelitis: report of nine cases and review of the literature. Reviews of infectious diseases. 1979 Sep 1;1(5):754-76.
16) Santhanam R, Lakshmi K. A retrospective analysis of the management of postoperative discitis: a single institutional experience. Asian Spine Journal. 2015 Aug;9(4):559.
17) Jiménez-Mejías ME, de Dios Colmenero J, Sánchez-Lora FJ, Palomino-Nicás J, Reguera JM, García de la Heras J, García-Ordoñez MA, Pachón J. Postoperative spondylodiskitis: etiology, clinical findings, prognosis, and comparison with nonoperative pyogenic spondylodiskitis. Clinical Infectious Diseases. 1999 Jul 15;29(2):339-45.
18) Rohde V, Meyer B, Schaller C, Hassler WE. Spondylodiscitis after lumbar discectomy: incidence and a proposal for prophylaxis. Spine. 1998 Mar 1;23(5):615-20.
19) Singh DK, Singh N, Das PK, Malviya D. Management of postoperative discitis: a review of 31 patients. Asian Journal of Neurosurgery. 2018 Jul;13(3):703.
20) Kang BU, Lee SH, Ahn Y, Choi WC, Choi YG. Surgical site infection in spinal surgery: detection and management based on serial C-reactive protein measurements. Journal of Neurosurgery: Spine. 2010 Aug 1;13(2):158-64.
21) Jain M, Sahu RN, Gantaguru A, Das SS, Tripathy SK, Pattnaik A. Postoperative lumbar pyogenic spondylodiscitis: An institutional review. Journal of neurosciences în rural practice. 2019 Jul;10(03):511-8.
22) Silber JS, Anderson DG, Vaccaro AR, Anderson PA, McCormick P. Management of postprocedural discitis. The Spine Journal. 2002 Jul 1;2(4):279-87.
23) Frangen TM, Kälicke T, Gottwald M, Andereya S, Andress HJ, Russe OJ, Müller EJ, Muhr G, Schinkel C. Surgical management of spondylodiscitis. An analysis of 78 cases. Der Unfallchirurg. 2006 Sep 1;109(9):743-53.
24) Refaat MI, Abdallah OY. Early surgical debridement and fixation for pyogenic lumbar spondylodiscitis. Egyptian Journal of Neurosurgery. 2020 Dec;35(1):1-5.
25) Paine KW, Cauchoix J, Mcivor G, Willis WK. Lumbar spinal stenosis. Clinical Orthopaedics and Related Research®. 1974 Mar 1;99:30-50.
26) Lee CK, Vessa P, Lee JK. Chronic disabling low back pain syndrome caused by internal disc derangements. The results of disc excision and posterior lumbar interbody fusion. Spine. 1995 Feb 1;20(3):356-61.


How to Cite this Article: Islam MA, Mahbub W, Saha S, Islam AI | Fusion with stabilization for the treatment of postoperative Lumbar spondylodiscitis: Our experience | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 84-89.  https://doi.org/10.13107/bbj.2022.v03i02.045

(Abstract Text HTML)      (Download PDF)


.

A Case Report of Aspergillus Fungal Spinal Infection in Immunocompetent Patient and Review of Literature

Volume 3 | Issue 2 | October 2022-March 2023 | page: 113-118 | Udit D. Patel, Hitesh N. Modi

DOI: https://doi.org/10.13107/bbj.2022.v03i02.049


Authors: Udit D. Patel [1], Hitesh N. Modi [1]

[1] Department of Spine Surgery, Zydus Hospitals and Healthcare Research Private Limited, Thaltej, Ahmedabad, Gujarat, India.

Address of Correspondence

Dr. Hitesh N. Modi,
Department of Spine Surgery, Zydus Hospitals and Healthcare Research Private Limited, Zydus hospital road, Thaltej, Ahmedabad, Gujarat, India.
E-mail: modispine@gmail.com


Abstract


Background: Spinal aspergillus infection is rare but can cause significant morbidity and mortality. Sometime it may mis-diagnosed as pyogenic or tuberculous infection in immunocompetent patients. Therefore, it causes delay in diagnosis and leads to spinal instability, neurological deficit, and sometimes death.
Case Report: Here we discussed a case of 68 years old female patient with severe back pain and difficulty in walking which was gradually increased over the period of time of two months. During this, she was diagnosed as koch’s spine based on MRI report and she had been started on empirical anti-tuberculous medication. But her condition was deteriorated. After that patient underwent surgical management and infected tissue sent for culture and sensitivity and histopathological examination. The report was positive for aspergillus fungal infection. she was started with anti-fungal medication and course of treatment was uneventful.
Conclusion: Early diagnosis of spinal fungal infection is often delayed in immunocompetent patients and it lead to delayed in anti-fungal management which lead to increase in morbidity and mortality.
Keywords: Aspergillus, Spinal fungal infection, Case Report


References


1. Zussman BS, Benjamin M, Penn MS, David L, Harrop MD, James S. Surgical management of fungal vertebral osteomyelitis. JHN Journal. 2011;6(2):2.
2. Casanova SR, Paulino R, Tavares J, Miranda AC, Sabino R, Veríssimo C, Toscano C, Mansinho K. Spondylodiscitis by Aspergillus nidulans: A Diagnostic Challenge. Journal of Microbiology and Infectious Diseases. 2021 Sep 1;11(03):162-5.
3. Batra S, Arora S, Meshram H, Khanna G, Grover SB, Sharma VK. A rare etiology of cauda equina syndrome. The Journal of Infection in Developing Countries. 2011;5(01):079-82.
4. Vaishya S, Sharma MS. Spinal Aspergillus vertebral osteomyelitis with extradural abscess: case report and review of literature. Surgical neurology. 2004 Jun 1;61(6):551-5.
5. Kim CW, Perry A, Currier B, Yaszemski M, Garfin SR. Fungal infections of the spine. Clinical Orthopaedics and Related Research (1976-2007). 2006 Mar 1;444:92-9.
6. Bazaz R, Denning DW. Aspergillosis: causes, types and treatment. Pharm. J. 2019;303:7927.
7. Dai G, Wang T, Yin C, Sun Y, Xu D, Wang Z, Luan L, Hou J, Li S. Aspergillus spondylitis: Case series and literature review. BMC Musculoskeletal Disorders. 2020 Dec;21(1):1-7.
8. Latgé JP, Chamilos G. Aspergillus fumigatus and Aspergillosis in 2019. Clinical microbiology reviews. 2019 Nov 13;33(1):e00140-18.
9. Perronne C, Saba J, Behloul Z, Salmon-Ceron D, Leport C, Vilde JL, Kahn MF. Pyogenic and tuberculous spondylodiskitis (vertebral osteomyelitis) in 80 adult patients. Clinical Infectious Diseases. 1994 Oct 1;19(4):746-50.
10. Yang H, Shah AA, Nelson SB, Schwab JH. Fungal spinal epidural abscess: a case series of nine patients. The Spine Journal. 2019 Mar 1;19(3):516-22.
11. Tew CW, Han FC, Jureen R, Tey BH. Aspergillus vertebral osteomyelitis and epidural abscess. Singapore Med J. 2009 Apr 1;50(4):e151-4.
12. Son JM, Jee WH, Jung CK, Kim SI, Ha KY. Aspergillus spondylitis involving the cervico-thoraco-lumbar spine in an immunocompromised patient: a case report. Korean Journal of Radiology. 2007 Oct 1;8(5):448-51.
13. Yoon KW, Kim YJ. Lumbar Aspergillus osteomyelitis mimicking pyogenic osteomyelitis in an immunocompetent adult. British Journal of Neurosurgery. 2015 Mar 4;29(2):277-9.
14. Raj KA, Srinivasamurthy BC, Nagarajan K, Sinduja MI. A rare case of spontaneous Aspergillus spondylodiscitis with epidural abscess in a 45-year-old immunocompetent female. Journal of Craniovertebral Junction and Spine. 2013 Jul;4(2):82.
15. Su KC, Chou KT, Hsiao YH, Tseng CM, Su VY, Lee YC, Perng DW, Kou YR. Measuring (1, 3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study. BMC infectious diseases. 2017 Dec;17(1):1-9.
16. Yeo SF, Wong B. Current status of nonculture methods for diagnosis of invasive fungal infections. Clinical microbiology reviews. 2002 Jul;15(3):465-84.
17. Lyons MK, Neal MT, Patel NP, Vikram HR. Progressive back pain due to Aspergillus nidulans vertebral osteomyelitis in an immunocompetent patient: surgical and antifungal management. Case Reports in Orthopedics. 2019 Jul 2;2019.
18. Patterson TF, Thompson III GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clinical infectious diseases. 2016 Aug 15;63(4):e1-60.
19. Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. New England Journal of Medicine. 2002 Aug 8;347(6):408-15.
20. Herbrecht R, Patterson TF, Slavin MA, Marchetti O, Maertens J, Johnson EM, Schlamm HT, Donnelly JP, Pappas PG. Application of the 2008 definitions for invasive fungal diseases to the trial comparing voriconazole versus amphotericin B for therapy of invasive aspergillosis: a collaborative study of the Mycoses Study Group (MSG 05) and the European Organization for Research and Treatment of Cancer Infectious Diseases Group. Clinical Infectious Diseases. 2015 Mar 1;60(5):713-20.
21. Koehler P, Tacke D, Cornely OA. Aspergillosis of bones and joints–a review from 2002 until today. Mycoses. 2014 Jun;57(6):323-35.
22. van Ooij A, Beckers JM, Herpers MJ, Walenkamp GH. Surgical treatment of aspergillus spondylodiscitis. European Spine Journal. 2000 Feb;9(1):75-9.
23. Gupta PK, Mahapatra AK, Gaind R, Bhandari S, Musa MM, Lad SD. Aspergillus spinal epidural abscess. Pediatric neurosurgery. 2001;35(1):18-23.
24. Chi CY, Fung CP, Liu CY. Aspergillus flavus epidural abscess and osteomyelitis in a diabetic patient. Journal of Microbiology, Immunology, and Infection. 2003 Jun 1;36(2):145-8.
25. Saigal G, Post MJ, Kozic D. Thoracic intradural Aspergillus abscess formation following epidural steroid injection. American journal of neuroradiology. 2004 Apr 1;25(4):642-4.
26. Chang HM, Yu HH, Yang YH, Lee WI, Lee JH, Wang LC, Lin YT, Chiang BL. Successful treatment of Aspergillus flavus spondylodiscitis with epidural abscess in a patient with chronic granulomatous disease. The Pediatric infectious disease journal. 2012 Jan 1;31(1):100-1.
27. Jiang Z, Wang Y, Jiang Y, Xu Y, Meng B. Vertebral osteomyelitis and epidural abscess due to Aspergillus nidulans resulting in spinal cord compression: Case report and literature review. Journal of international medical research. 2013 Apr;41(2):502-10.
28. McCaslin AF, Lall RR, Wong AP, Lall RR, Sugrue PA, Koski TR. Thoracic spinal cord intramedullary aspergillus invasion and abscess. Journal of Clinical Neuroscience. 2015 Feb 1;22(2):404-6.
29. Shweikeh F, Zyck S, Sweiss F, Sangtani A, Shweikeh M, Issa H, Steinmetz MP, Markarian GZ. Aspergillus spinal epidural abscess: Case presentation and review of the literature. Spinal Cord Series and Cases. 2018 Mar 7;4(1):1-9.
30. Ono R, Uehara K, Kitagawa I. Emphysematous osteomyelitis of the spine: a case report and literature review. Internal Medicine. 2018 Jul 15;57(14):2081-7.
31. Senosain-Leon V, Hidalgo-Benites A, Arriola-Montenegro J, D’Angelo-Piaggio L, Beas R. Invasive pulmonary aspergillosis with Aspergillus vertebral osteomyelitis in an HIV-infected adult: a case report. International journal of STD & AIDS. 2019 Oct;30(11):1140-2.
32. Aghapoor M, Alijani BA. Aspergillus Spondylodiscitis After Spinal Stenosis Surgery: A Case ReportA Case Report. Iranian Journal of Neurosurgery. 2019 Nov 10;5(3):155-60.
33. Takagi Y, Yamada H, Ebara H, Hayashi H, Kidani S, Okamoto S, Nakamura Y, Kitano Y, Kagechika K, Demura S, Ueno T. Aspergillus terreus spondylodiscitis following an abdominal stab wound: a case report. Journal of Medical Case Reports. 2019 Dec;13(1):1-6.
34. Perna A, Ricciardi L, Fantoni M, Taccari F, Torelli R, Santagada DA, Fumo C, Tamburrelli FC, Proietti L. Spontaneous Vertebral Aspergillosis, the State of Art: A Systematic Literature Review. Neurospine. 2021 Mar;18(1):23.
35. Makhdoomi R, Malik N, Charan J, Malik A, Singh S. Spinal aspergillosis: a rare complication of COVID-19 infection. Egyptian Journal of Neurosurgery. 2022 Dec;37(1):1-3.


How to Cite this Article: Patel UD, Modi HN |  A Case Report of Aspergillus Fungal Spinal Infection in Immunocompetent Patient and Review of Literature | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 113-118. https://doi.org/10.13107/bbj.2022.v03i02.049

(Abstract Text HTML)      (Download PDF)


Patient and Parent’s Knowledge, Emotion and Expectation Evaluation in Conservatively Treated Adolescent Idiopathic Scoliosis: A Prospective Randomized Study in 200 Children by a Simple Questionnaire

Volume 3 | Issue 2 | October 2022-March 2023 | page: 96-108 | Hitesh N. Modi, Seung-Woo Suh, Jae-Young Hong, Jae-Hyuk Yang

DOI: https://doi.org/10.13107/bbj.2022.v03i02.047


Authors: Hitesh N. Modi [1, 2], Seung-Woo Suh [1], Jae-Young Hong [1], Jae-Hyuk Yang [1]

 

[1] Scoliosis Research Institute, Department of Orthopaedics, Korea University Guro Hospital, Seoul, South Korea.
[2] Department of Orthopaedics, Zydus Hospital and Healthcare Research Pvt Ltd, Ahmedabad, Gujarat, India.

Address of Correspondence

Dr Seung-Woo Suh,
Scoliosis Research Institute, Department of Orthopaedics, Korea University Guro Hospital, 80 Guro-Dong, Guro-Gu, Seoul, South Korea.
E-mail: spine@korea.ac.kr


Abstract


Objectives: To find out if any disparity of the knowledge regarding the scoliosis, treatment, psychological status and treatment satisfaction between different groups of children based on age, follow-up or treatment modality (bracing or observation) and, between patients and their parents.
Summary of Background Data. There are numerous questionnaires available in scoliosis which specifically measures either operative outcome or bracing outcomes in terms of general appearance, psychological appearance or pain scores. There is no questionnaire available that evaluate the overall general knowledge, their psychological status regarding the treatment, knowledge regarding future such as progression of curve, marriage, pregnancy and health status as well as their expectations and choices from the treatment in conservatively treated AIS patients.
Methods: Study was conducted in 200 children with adolescent idiopathic scoliosis (AIS) with age between 10 and 16 years. All 30 questions were divided into four subgroups to evaluate 1) General knowledge (Q 1-9); 2) Emotional and psychological status (Q 10-16); 3) Treatment knowledge (Q 17-25); and 4) Treatment satisfaction (Q 26-30). Results were evaluated based on treatment modality (bracing or observation); duration of follow-up (less than or more than 12 months), and age (less than or more than 13 years), and also between patients and parents.
Results: General knowledge remains the same (p>0.05) in all subgroups, while treatment knowledge was higher in parents (p<0.0001) and in patients with follow-up more than 12 months (p=0.0009) while age of patients didn’t show any difference (p=0.083). Psychological disturbances were found more in parents (p=0.046), and patients with longer follow-up (p=0.001) and higher age (p=0.002). Similarly, parents (p<0.0001), and patients with follow-up more than 12 months (0.011) and age more than 13 years (p=0.009) had higher treatment dissatisfaction. However, the treatment modality (bracing or observation) didn’t exhibit any difference (p>0.05) in any questionnaire.
Conclusion: We evaluated general and treatment knowledge, psychological and mental status and treatment satisfaction from a single and simple questionnaire in conservatively treated AIS subjects, which would provide useful information to handle the different issues involved with the disease.
Keywords: Adolescent idiopathic scoliosis, Conservative treatment, Questionnaire, Evaluation.


References


1. Lonstein JE, Carlson JM. The prediction of curve progression in untreated idiopathic scoliosis during growth. J Bone Joint Surg Am 1984; 66:1061–71.
2. Stagnara P: Les deformations du rachis. Paris,; 1976.
3. Osmond-Clarke H: Scoliosis. In The Milwaukee Brace Edited by: Blount WP and Moe JH. Baltimore, The William and Wilkins Company; 1973.
4. Hall JE: Controversial issues in spinal deformity surgery. J Pediatr Orthop 1997, 17:701-702.
5. Jacob J. Consumer access to health care information: its effect on the physician- patient relationship. Alaska Med 2002; 44:75–82.
6. Uong EC, Jeffe DB, Gozal D, et al. Development of a measure of knowledge and attitudes about obstructive sleep apnea in children (OSAKA-KIDS). Arch Pediatr Adolesc Med 2005; 159:181–6.
7. Wagner J, Lacey K, Chyun D, et al. Development of a questionnaire to measure heart disease risk knowledge in people with diabetes: the Heart Disease Fact Questionnaire. Patient Educ Couns 2005; 58:82–7.
8. Brosnan H. Nursing management of the adolescent with idiopathic scoliosis. Nurs Clin North Am 1991;26:17–31.
9. Roach JW. Nonsurgical treatment. In: Weinstein SL, ed. The Pediatric Spine: Principles and Practice. New York, NY: Raven Press; 1994: chap 23.
10. Weinstein SL, Dolan LA, Spratt KF, et al. Health and function of patients with untreated idiopathic scoliosis: a 50-year natural history study. JAMA 2003; 289:559–67.
11. Sanders JO, Harrast JJ, Kulo TR et al. The spinal appearance questionnaire. Results of reliability, validity, and responsiveness testing in patients with idiopathic scoliosis. Spine 2007; 32(24):2719-22.
12. Bridwell KH, Shufflebarger HL, Lenke LG, et al. Parents’ and patients’ preferences and concerns in idiopathic adolescent scoliosis: a cross-sectional preoperative analysis. Spine 2000; 25:2392–9.
13. Rinella A, Lenke L, Peelle M, et al. Comparison of SRS questionnaire results submitted by both parents and patients in the operative treatment of idiopathic scoliosis. Spine 2004; 29:303–10.
14. Smith PL, Donaldson S, Hedden D, et al. Parents’ and patients’ perceptions of postoperative appearance in adolescent idiopathic scoliosis. Spine 2006; 31: 2367–74.
15. Climent JM, Reig A, Sanchez J, et al. Construction and validation of a specific quality of life instrument for adolescents with spine deformities. Spine 1995; 20:2006–11.
16. Climent JM, Sanchez J. Impact of the type of brace on the quality of life of adolescents with spine deformities. Spine 1999; 24:1903–8.
17. Weiss HR, Werkmann M, Stephan C. Brace related stress in scoliosis patients- comparison of different concepts of bracing. Scoliosis 2007; 2:10.
18. Lai SM, Asher M, Burton D. Estimating SRS-22 quality of life measures with SF-36. Application in idiopathic scoliosis. Spine 2006; 31(4):473-478.
19. Khetani N, Donaldson S, Wright JG. What do patients and parents know about surgery for adolescent idiopathic scoliosis? A knowledge questionnaire. Spine 2008; 33(20):E754-758.
20. Guyatt G, Bombardier C, Tugwell P. Measuring disease-specific quality of life in clinical trials. Can Med Assoc J. 1986;134:889-895.
21. Patrick D, Deyo R. Generic and disease-specific measures in assessing health status and quality of life. Med Care. 1989;27:S217-S232.
22. Haher T, Gorup J, Shin T, et al. Results of the Scoliosis Research Society instrument for evaluation of surgical outcome in adolescent idiopathic scoliosis. Spine 1999; 24:1435–1440.
23. White S, Asher M, Lai S, et al. Patients’ perceptions of overall function, pain and appearance after primary posterior instrumentation and fusion for idiopathic scoliosis. Spine 1999; 24:1693–1700.
24. Whati LH, Senekal M, Steyn NP, et al. Development of a reliable and valid nutritional knowledge questionnaire for urban South African adolescents. Nutrition 2005;21:76–85.
25. Clayson D, Luz-Alterman S, Cataletto M, Levine DB: Long term psychological sequalae of surgically versus nonsurgically treated scoliosis. Spine 1984, 12(10):983-986.
26. MacLean WE, Green NE, Pierre CB, Ray DC: Stress and Coping with scoliosis, Psychological effects on adolescents and their families. Journal of Paediatric Orthopaedic 1989, 9(3):257-261.
27. Payne WK 3rd, Ogilvie JW, Resnick MD, Kane RL, Transfeldt EE, Blum RW: Does scoliosis have a psychological impact and does gender makes a difference? Spine 1997, 22(12):1380-4.
28. Freidel K, Petermann F, Reichel D, Steiner A, Warschburger P, Weiss HR: Quality of Life in Women With Idiopathic Scoliosis. Spine 2002, 27(4):87-91.
29. Ugwonali OF, Lomas G, Choe JC, Hyman JE, Lee FY, Vitale MG, Roye DP Jr: Effect of bracing on the quality of life of adolescents with idiopathic scoliosis. Spine 2004, 4(3):254-60.
30. Weiss HR: How much stress do scoliosis patients have because of their brace? Proceedings of the 3rd. International Conference on Conservative Management of Spinal Deformities & Scientific meeting of the SOSORT, April 7th. – 8th., Poznan, 2006 .
31. Kotwicki T, Kinel E, Stryła W, Szulc A: Estimation of the stress related to conservative scoliosis therapy: an analysis based on BSSQ questionnaires. Scoliosis 2007, 2:1.
32. Linderman M, Behm K. Cognitive strategies and self esteem as predictors of brace-wear noncomplicance in patients with idiopathic scoliosis and kyphosis. J Pediatr Orthop 1999; 19:493-499.


How to Cite this Article: Modi HN, Suh SW, Hong JY, Yang JH | Patient and Parent’s Knowledge, Emotion and Expectation Evaluation in Conservatively Treated Adolescent Idiopathic Scoliosis: A Prospective Randomized Study in 200 Children by a Simple Questionnaire | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 96-108. https://doi.org/10.13107/bbj.2022.v03i02.047

(Abstract Text HTML)      (Download PDF)


Gorham Stout Disease- A Rare Disorder with Ambiguous Recommendations: A Systematic Review of literature.

Volume 3 | Issue 2 | October 2022-March 2023 | page: 65-77 | Ajay Krishnan, Preethesh Agrawal, Vatsal Parmar, Vikrant Chauhan, Devanand Degulmadi, Shivanand Mayi, Ravi Ranjan, Shiv Kumar Bali, Prartham C Amin, Pranav R Charde, Preety A Krishnan, Mirant R Dave, Bharat R Dave

DOI: https://doi.org/10.13107/bbj.2022.v03i02.043


Authors: Ajay Krishnan [1], Preethesh Agrawal [1], Vatsal Parmar [1], Vikrant Chauhan [1], Devanand Degulmadi [1], Shivanand Mayi [1], Ravi Ranjan [1], Shiv Kumar Bali [1], Prartham C Amin [1], Pranav R Charde [1], Preety A Krishnan [2], Mirant R Dave [1], Bharat R Dave [1]

[1] Department of Spine Surgery, Stavya Spine Hospital & Research Institute, Mithakhali, Ellisbridge, Ahmedabad, Gujarat, India.
[2] Department of Radiology, Stavya Spine Hospital & Research Institute, Mithakhali, Ellisbridge, Ahmedabad, Gujarat, India.

Address of Correspondence

Dr. Ajay Krishnan,
Department of Spine Surgery, Stavya Spine Hospital & Research Institute, Mithakhali, Ellisbridge, Ahmedabad, Gujarat, India.
E-mail: drajaykrishnan@gmail.com


Abstract


Background: Vanishing bone disease / Gorham-Stout disease (GSD) is a condition that produces deformity and instability of bone. The fibro lympho-vascular tissue replaces the bone leading to massive osteolysis and its sequelae, but the exact cause is yet unknown. The disease involves the spine infrequently, but due to the proximity of the spinal cord it can seriously affect the patient. The aim of this study is to report as a review to contribute to the diagnosis, and treatment modalities in GSD affection of spine with the reported literature available from 1983 till March 2022.
Materials & Method: This metanalysis study is focused on GSD involving the spine. The search was done in two databases PubMed and Google scholar from 1983 up to March 2022. The Study selection was done to study the demographic pattern of GSD in spine and its outcome with conservative and surgical treatment and to determine the best suitable medical treatment for stopping disease progression and achieving remission.
Results: We retrieved 72 articles from Google scholar and PubMed out of which 5 articles were excluded (90 reported cases). Heffez criteria was followed for diagnosis in all these cases (n=86, 95.5%). 57 patients (64%) were operated and 33 patients (36%) were managed conservatively. Per-operative failure to achieve a fixation/reconstruction were reported in 2 (2.53%) cases. Number of surgeries till follow-up were average 1.70+ 1.23 (1-5) surgeries. The average follow-up of cases reported was 47.1+ 48.9 (3-240 months). Union was documented in 10 cases (3.4%). 9 of these cases needed additional bone graft/substitute. Bisphosphonates(n=40), sirolimus (n=5), interferon (n=17), radiotherapy (n= 31) and beta-blockers (n=4) were given in medications. 23 patients had remission. Death occurred in 17 patients (18.88%).
Conclusion: Surgery is needed frequently. Failure of fixations, achieving union and remission are daunting and ’off  label” therapies are the dictum. Radiotherapy has been used more frequently with or without bisphosphonates. Though promising medical treatment are evolving and focus of treatment is directed towards anti-angiogenic, anti-osteolytic and anabolic therapy, but no standard treatment recommendations can be made out from existing literature.
Keywords: Vanishing bone disease, Gorham stout, Osteolysis, Spine, Deformity, Sirolimus, TNF


References


1. Dickson GR, Hamilton A, Hayes D, Carr KE, Davis R, Mollan RAB. An investigation of vanishing bone disease. Bone. 1990;11(3):205–210.
2. Gorham lw sa. Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone); its relation to hemangiomatosis. J Bone Jt Surg Am. 1995;37(5):985–1004.
3. Nikolaou VS, Chytas D, Korres D, Efstathopoulos N. Vanishing bone disease (gorham-stout syndrome): A review of a rare entity. World J Orthop. 2014;5(5):694–698.
4. Sekharappa V, Arockiaraj J, Amritanand R, Krishnan V, David KS, David SG. Gorham’s disease of spine. Asian Spine J. 2013;7(3):242–247.
5. Momanu A, Caba L, Gorduza NC, Arhire OE, Popa AD, Ianole V, et al. Gorham-stout disease with multiple bone involvement—challenging diagnosis of a rare disease and literature review. Med. 2021;57(7):1–11.
6. Dellinger MT, Garg N, Olsen BR. Viewpoints on vessels and vanishing bones in Gorham-Stout disease. Bone [Internet]. 2014;63:47–52.
7. Grönroos M, Palomäki A. Young adult with Gorham’s disease presenting in an emergency department: a case report. J Med Case Rep. 2021;15(1):1–4.
8. Du CZ, Li S, Xu L, Zhou QS, Zhu ZZ, Sun X, et al. Spinal Gorham-Stout syndrome: Radiological changes and spinal deformities. Quant Imaging Med Surg. 2019;9(4):565–578.
9. Patel DV. Gorham’s disease or massive osteolysis. Clin Med Res. 2005;3:65–74.
10. Avelar RL, Martins VB, Antunes AA, de Oliveira Neto PJ AE. Use of zoledronic acid in the treatment of Gorham’s disease. Int J Pediatr Otorhinolaryngol. 2010;74:319–22.
11. Koto K, Inui K, Itoi M, Itoh K. Gorham-Stout disease in the rib and thoracic spine with spinal injury treated with radiotherapy, zoledronic acid, vitamin D, and propranolol: A case report and literature review. Mol Clin Oncol. 2019;11(6):551–556.
12. Dominguez R, Washowich TL. Pediatric Radiology plain film , CT , and MRI findings of two cases. 1994;316–318.
13. Tateda S, Aizawa T, Hashimoto K, Kanno H, Ohtsu S, Itoi E, et al. Successful management of gorham-stout disease in the cervical spine by combined conservative and surgical treatments: A case report. Tohoku J Exp Med. 2017;241(4):249–254.
14. Tilling G SB. Disappearing bone disease, Morbus Gorham: report of a case. Acta Orthop Scand. 1968;39:398–406.
15. Ali Akbar Esmailiejah, Naser Kamalian MA. Temporary Paraplegia resulting from Groham’s disease involving the third lumbar vertebrae and proximal femur: A five year Follow-up and review of the literarture. Arch Iran Med. 2013;16(11):686–690.
16. Paley MD, Lloyd CJ PC. Total mandibular reconstruction for massive osteolysis of the mandible. Br J Oral Maxillofac Surg. 2005;43:166–168.
17. Vinée P, Tanyü MO, Hauenstein KH, Sigmund G, Stöver B AC. CT and MRI of Gorham syndrome. J Comput Assist Tomogr. 1994;18:985–989.
18. Yoo SY, Hong SW. Chung HW, Choi JA, Kim CJ KH. MRI of the Gorham’s disease: finding in two cases. Skelet Radiol. 2002;31:301–306.
19. Heffez L, Feeney JE, Carter BL. Perspectives on massive osteolysis: report of a case and review of the literature. Oral Surgery, Oral Med Oral Pathol. 1993;55(4):331–343.
20. Ruggieri P, Montalti M, Angelini A, Alberghini M, Mercuri M. Gorham-Stout disease: The experience of the Rizzoli Institute and review of the literature. Skeletal Radiol. 2011;40(11):1391–1397.
21. Chang-Zhi Du, Song Li, Liang Xu, Qing-Shuang Zhou, Ze-Zhang Zhu, Xu Sun YQ. Spinal Gorham-Stout syndrome: radiological changes and spinal deformities. Quant Imaging Med Surg. 2019;9(4):565–578.
22. Ibrahim Saeed Gataa, Noroz Hama R. Nader Y, Abdallah DT. Massive Craniofacial Gorham Disease Treated Successfully by Cisplatin and 5-Fluorouracil With Ten Years of Follow-Up: A Case Report and Literature Review. J Oral Maxillofac Surg. 2016;74(9):1774–1782.
23. DevlinRD, BoneHG3rd R. Interleukin-6: a potential mediator of the massive osteolysis in patients withGorham– Stout disease. J Clin EndocrinolMetab. 1996;81:1893–1897.
24. Colucci S, Taraboletti G, Primo L, Viale A, Roca C, Valdembri D, Geuna M, Pagano M, Grano M, Pogrel AM et al. Gorham‑Stout syndrome: A monocyte‑mediated cytokine propelled disease. J Bone Min Res. 2006;21:207–18.
25. Dupond J-L, Bermont L, Runge M de BM. Plasma VEGF determination in disseminated lymphangiomatosis-Gorham– Stout syndrome. A marker of activity? A case report with a 5 years follow-up. Bone. 2010;46:873–876.
26. Kulenkampff HA, Richter GM, Hasse WE et al. Massive pelvic osteolysis in the Gorham-Stout syndrome. Int Orthop. 1990;14:361–366.
27. Cannon SR. Massive osteolysis. A review of seven cases. J Bone Jt Surg – Ser B. 1986;68(1):24–28.
28. Hardegger F, Simpson LA SG. The syndrome of idiopathic osteolysis. Classification, review, and case report. J Bone Jt Surg Br. 1985;67:88–93.
29. Lee BB, Rockson SG BJ. Lymphedema: a concise compendium of theory and practice. Springer. 2018;
30. P.J. L, Saifuddin A, Webb PJ, Mitchell N, Ramani P. Gorham’s disease of the spine. Skeletal Radiol. 1996;25:403–405.
31. Liu S, Zhou X, Song A, Kong X, Wang Y, Liu Y. Successful treatment of Gorham-Stout syndrome in the spine by vertebroplasty with cement augmentation: A case report and literature review. Med (United States). 2018;97(29):1–6.
32. Kahn HJ, Bailey D MA. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi’s sarcoma and a subset of angiosarcomas. Mod Pathol. 2002;15(4):434–440.
33. Krishnan A, Raj A, Degulmadi D, Mayi S, Rai R, Bali SK, et al. Gorham-Stout disease: A multirod lumbar reconstruction with off-label suppression-remission therapy. Surg Neurol Int. 2022;13(136):1–5.
34. Bouloux GF, Walker DM MG. Massive osteolysis of the mandible: Report of a case with multifocal bone loss. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87(3):357–361.
35. Sharma A, Iyer N, Mittal A, Das D SS. Vanishing mandible. J Oral Sci. 2012;52(3):513–516.
36. Tong A, Leung T, Surgery PC. Management of massive osteolysis of the mandible: a case report. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2010;109(2):238–41.
37. Gondivkar SM GA. Gorham-Stout syndrome: a rare clinical entity and review of literature. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2010;109(2):41–48.
38. Brodszki N, Länsberg JK, Dictor M, Gyllstedt E, Ewers SB, Larsson MK, et al. A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax. Acta Paediatr Int J Paediatr. 2011;100(11):1448–1453.
39. Tena-Sanabria ME, Jesús-Mejenes LY, Fuentes-Herrera G, Álvarez-Martínez FA, Victorio-García NP, Núñez-Enríquez JC. A report of two children with Gorham-Stout disease. BMC Pediatr. 2019;19(1):1–7.
40. Vanhoenacker FM, De Vuyst D, Vandervliet E, Veyt A, Vangeneugden J. Paget’s disease with vanishing bone pattern and spinal fusion. J Belge Radiol. 2007;90(5):388–390.
41. Damron TA, Brodke DS, Heiner JP, Swan JS DS. Gorham’s disease (Gorham-Stout syndrome) of scapula. Skelet Radiol. 1993;22:464–467.
42. Martín Noguerol T, Barousse R, Socolovsky M LA. A. Quantitative magnetic resonance (MR) neurography for evaluation of peripheral nerves and plexus injuries. Quant Imaging Med Surg. 2017;7:398–421.
43. Mawk JR, Obukhov SK, Nichols WD, Wynne TD, Odell JM, Urman SM. Successful conservative management of Gorham disease of the skull base and cervical spine. Child’s Nerv Syst. 1997;13:622–625.
44. Granado Peña JM, Báez Marrero O, Sosa Henríquez M. Gorham’s disease of the cervical spine. Case report. Neurocirugia. 1995;6(2):156–160.
45. Boyer, P.; Bourgeois, P.; Boyer, O.; Catonne, Y.; Saillant G. Massive Gorham-Stout syndrome of the pelvis. Clin Rheumatol. 2005;24:551–555.
46. Aizawa T, Sato T, Kokubun S. Gorham disease of the spine: A case report and treatment strategies for this enigmatic bone disease. Tohoku J Exp Med. 2005;205(2):187–196.
47. Kakuta Y, Iizuka H, Kobayashi R, Iizuka Y, Takahashi T, Mohara J, et al. Gorham disease of the lumbar spine with an abdominal aortic aneurysm: A case report. Spine J. 2014;14(1):5–9.
48. Chong Ng L, Sell P. Gorham disease of the cervical spine-a case report and review of the literature. Spine (Phila Pa 1976). 2003;28(18):355–358.
49. Barman A, Bhide R, Viswanathan A, George J, Thomas R, Tharion G. Gorham’s disease of the spine. NeuroRehabilitation. 2013;33(1):121–126.
50. Tie ML, Poland GA RE 3rd. Chylothorax in Gorham’s syndrome. A common complication of a rare disease. Chest. 1994;105(1):208–213.
51. Ellati R, Attili A, Haddad H, Al-Hussaini M SA. Novel approach of treating Gorham-Stout disease in the humerus: Case report and review of literature. Eur Rev Med Pharmacol Sci. 2016;20(3):426–432.
52. Mo AZ, Trenor CC, Hedequist DJ. Sirolimus Therapy as Perioperative Treatment of Gorham-Stout Disease in the Thoracic Spine A Case Report. JBJS Case Connect. 2018;8(3):1-7.
53. Manisali, M. & Ozaksoy D. Gorham disease: correlation of MR findings with histopathologic changes. Eur Radiol. 1998;8:1647–1650.
54. William H. Edwards, Roby c.thompson E varsa. Lymphangiomatosis and massive osteolysis of the cervical spine. Clin Orthop Relat Res. 1983;222–9.
55. Dunbar SF, Rosenberg A, Mankin H, Rosenthal D, Suit HD. Gorham’s massive osteolysis: the role of radiation therapy and a review of the literature. International Journal of Radiation Oncology* Biology* Physics. 1993 Jun 15;26(3):491-497.
56. Drewry GR, Martinez CR, Brantley SG. Gorham disease of the spine. Spine (Phila Pa 1976). 1994;19(19):2213–22.
57. Foult H, Goupille P, Aesch B, Valat JP, Burdin P JM. Massive osteolysis of the cervical spine. A case report. Spine (Phila Pa 1976). 1995;20(14):1636–1639.
58. Hans Hagberg, Kristina Lamberg GÅ. a-2b interferon and oral clodronate for Gorham’s disease. Lancet. 1997;350:1822–1823.
59. Khosrovi H, Ortiz O, Kaufman HH, Schocket SS, Reddy GN, Simmons D. Massive osteolysis of the skull and upper cervical spine: Case report and review of the literature. J Neurosurg. 1997;87(5):773–780.
60. Bode-Lesniewska B, Hochstetter A von, Exner GU, Hodler J. Gorham-Stout disease of the shoulder girdle and cervico-thoracic spine: fatal course in a 65-year-old woman. Skelet Radiol. 2002;31:724–729.
61. Duffy BM, Manon R, Patel RR, Welsh JS. A case of Gorham’s disease with chylothorax treated curatively with radiation therapy. Clin Med Res. 2005;3(2):83–86.
62. Takahashi A, Ogawa C, Kanazawa T, Watanabe H, Suzuki M, Suzuki N, et al. Remission induced by interferon alfa in a patient with massive osteolysis and extension of lymph-hemangiomatosis: A severe case of Gorham-Stout syndrome. J Pediatr Surg. 2005;40(3):47–50.
63. Girn HRS, Towns G, Chumas P, Holland P, Chakrabarty A. Gorham’s disease of skull base and cervical spine – Confusing picture in a two year old. Acta Neurochir (Wien). 2006;148(8):909–913.
64. B. Kai, A. Ryan, P.L. Munk PD. Gorham disease of bone: three cases and review of radiological features. Clin Radiol. 2006;61:1058–1064.
65. Lekovic GP, Mariwalla NR, Horn EM, Chang S, Rekate HL, Theodore N. Skeletal dysplasia involving the subaxial cervical spine: Report of two cases and review of the literature. Neurosurgical focus. 2006 Feb 1;20(2):1-6.
66. Lehmann G, Pfeil A, Böttcher J, Kaiser WA, Füller J, Hein G, et al. Benefit of a 17-year long-term bisphosphonate therapy in a patient with Gorham-Stout syndrome. Arch Orthop Trauma Surg. 2009;129(7):967–972.
67. Kose M, Pekcan S, Dogru D, Akyuz C, Ozcelik U, Ozsurekci Y, et al. Gorham-Stout syndrome with chylothorax: Successful remission by interferon alpha-2b. Pediatr Pulmonol. 2009;44(6):613–615.
68. Sarah Mowry, MD; Rinaldo Canalis, MD F. Gorham-Stout Disease of the Temporal Bone. Laryngoscope. 2010;120:598–600.
69. Adler F, Gupta N, Hess CP, Dowd CF, Dillon WP. Intraosseous CSF fistula in a patient with Gorham disease resulting in intracranial hypotension. Am J Neuroradiol. 2011;32(11):198–200.
70. Deveci M, Nagihan İ, Çorapç F. Gorham-Stout Syndrome with Chylothorax in a Six-Year-Old Boy. 2011;78(June):737–739.
71. Heyd R, Micke O, Surholt C, Berger B, Martini C, Füller J, Schimpke T, Seegenschmiedt MH, German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD. Radiation therapy for Gorham-Stout syndrome: results of a national patterns-of-care study and literature review. International Journal of Radiation Oncology* Biology* Physics. 2011 Nov 1;81(3):179-185.
72. Rajendra Kumar Sahoo, Balavenkatasubramanian Jagannathan G, Palanichamy VN. Anaesthetic consideration in patients with Gorham ’ s syndrome : A case report and review of the literature. 2012;56(4):391–394.
73. Noda M, Endo C, Hoshikawa Y, Ishibashi N, Suzuki T, Okada Y, et al. Successful management of intractable chylothorax in Gorham-Stout disease by awake thoracoscopic surgery. Gen Thorac Cardiovasc Surg. 2013;61(6):356–358.
74. Zheng MW, Yang M, Qiu JX, Nan XP, Huang LY, Zhang WD, Gong L, Huang ZZ. Gorham-Stout syndrome presenting in a 5-year-old girl with a successful bisphosphonate therapeutic effect. Experimental and Therapeutic Medicine. 2012 Sep 1;4(3):449-451.
75. Kilicoglu ZG, Kis NK, Aker FV, Berkman MZ, Simsek MM. Gorham disease of the craniocervical junction: X-ray, computed tomography, and magnetic resonance imaging findings. The Spine Journal. 2013 May 1;13(5):11-14..
76. Maillot C, Cloche T, Le Huec JC. Thoracic osteotomy for Gorham-Stout disease of the spine: a case report and literature review. European Spine Journal. 2014;27(9):2285-2290.
77. Molina EJ, Niederstadt T, Ruland V, Kayser G, Stummer W, Ewelt C, Rössler J. Cerebrospinal fluid leakage in Gorham-Stout disease due to dura mater involvement after progression of an osteolytic lesion in the thoracic spine: Case report. Journal of Neurosurgery: Spine. 2014 Dec 1;21(6):956-960.
78. Vered Nir, MD, , Ludmila Guralnik, MD, Galit Livnat, MD, Ronen Bar-Yoseph M, Fahed Hakim, MD, Anat Ilivitzki, MD, and Lea Bentur M. Propranolol as a Treatment Option in Gorham–Stout Syndrome: A Case Report. Pediatr Pulmonol. 2014;49:417–419.
79. Kohno M, Aota Y, Kawai T, Murata H, Saito T. Surgical Treatment of Gorham’s Disease with Massive Osteolysis of the Skull and Cervical Spine: A Case Report and Review of Literature. NMC Case Rep J. 2015;2(2):80–84.
80. Ganal-Antonio AK, Samartzis D, Bow C, Cheung KM, Luk KD, Wong YW. Disappearing bone disease of the humerus and the cervico-thoracic spine: a case report with 42-year follow-up. The Spine Journal. 2016 Feb 1;16(2):67-75.
81. Carbó E, Riquelme Ó, García A, González JL. Vertebroplasty in a 10-year-old boy with Gorham–Stout syndrome. Eur Spine J. 2015;24:590–593.
82. Kim MK, Hong JR, Kim SG, Lee SK. Fatal Progression of Gorham Disease: A Case Report and Review of the Literature. J Oral Maxillofac Surg. 2015;73(12):2352–2360.
83. Pn G, Ac D, An P. A Rare Case of Progressive Gorham’s Disease of Right Shoulder Girdle and Cervical Spine in A Child: 10 Year Follow-up and A Review of Literature. J Orthop case reports. 2015;5(4):30–33.
84. Rössler J, Saueressig U, Kayser G, Von Winterfeld M, Klement GL. Personalized therapy for generalized lymphatic anomaly/gorham-stout disease with a combination of sunitinib and taxol. J Pediatr Hematol Oncol. 2015;37(8):481–485.
85. Adam Schell, John M. Rhee, Abigail Allen, Lindsay Andras FZ. Surgical management of gorham disease involving the upper cervical spine with occipito-cervical-thoracic fusion: a case report. Spine J. 2016;1–11.
86. Srivastava SK, Aggarwal RA, Nemade PS, Bhoale SK. Vanishing bone disease of chest wall and spine with kyphoscoliosis and neurological deficit: A case report and review of literature. Indian J Orthop. 2017;51(1):107–114.
87. Alexandre Jaccard, César Macedo, Gabriel Castro AG. Thoracic spine dislocation in Gorham–Stout Syndrome: Case report and literature review. Surg Neurol Int. 2018;9(223):1–3.
88. Wang P, Liao W, Cao G, Jiang Y. A rare case of Gorham-stout syndrome involving the thoracic spine with progressive bilateral chylothorax: A case report. BMC Musculoskelet Disord. 2019;20(1):1–6.
89. Jung Hwa Kim, MD, Do Heum Yoon, MD. PhD, Keung Nyun Kim, MD. PhD DA, Shin, MD. PhD, Seong Yi, MD. PhD, Jiin Kang, MD, Yoon Ha MP. Surgical management of Gorham-Stout disease in cervical compression fracture with cervico-thoracic fusion: A Case report and review of literature. World Neurosurg. 2019;129:277–281.
90. Barbagli G, Barni I, Romoli S. A rare case of spine disappearing bone disease: Lesson learned and review of the literature. Interdisciplinary Neurosurgery. 2019 Sep 1;17:79-83.
91. Simon F, Luscan R, Khonsari RH, Toubiana J, Belhous K, James S, Blauwblomme T, Zerah M, Denoyelle F, Donadieu J, Couloigner V. Management of Gorham Stout disease with skull-base defects: case series of six children and literature review. International Journal of Pediatric Otorhinolaryngology. 2019 Sep 1;124:152-156.
92. Chang K, Yang M, Li B, Huang H. Surgical management of Gorham‑Stout syndrome involving the cervical spine with bilateral pleural effusion: A case report and literature review. Exp Ther Med. 2020;19:3851–3855.
93. Hana Yokoi, Vikram Chakravarthy, Benjamin Whiting, Scott E. Kilpatrick, Tsulee Chen AK. Gorham-Stout disease of the spine presenting with intracranial hypotension and cerebrospinal fluid leak: A case report and review of the literature. Surg Neurol Int. 2020;11(466):1–4.
94. Chloe Gui1, Brett Rocos, Laura-Nanna Lohkamp, Angela Cheung, Robert Bleakney EM. Utility of the spinal instability neoplastic score to identify patients with Gorham-Stout disease requiring spine surgery. Surg Neurol Int. 2021;12(227):1–3.
95. Toga A, Watanabe K, Suzuki S, Nori S, Tsuji O, Nagoshi N, et al. Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy: A Case Report. JBJS case Connect. 2021;11(1):1–5.
96. Harman YG and F. The loneliness of a long-distance runner. A ten-year survey of a patient diagnosed with Gorham-Stout syndrome at the occipitocervical junction. Br J Neurosurg. 2021;1–4.
97. Aleksey Evsyukov, Murodzhon Kosimshoev, Yuliy Kubetskyi EN and JR. Surgical treatment of a patient with Gorham-Stout disease of craniovertebral junction: case report and literature review. Br J Neurosurg. 2021;1–6.
98. Ashley Ann Thompson SP. Gorham- Stout disease of the mandible, manubrium and cervical spine presenting as bilateral chylothorax. BMJ Case Rep. 2021;14(1):1–3.


How to Cite this Article: Krishnan A, Agrawal P, Parmar V, Chauhan V, Degulmadi D, Mayi S, Ranjan R, Bali SK, Amin PC, Charde PR, Krishnan PA, Dave MR, Dave BR | Gorham Stout Disease- A Rare Disorder with Ambiguous Recommendations: A Systematic Review of literature | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 65-77.  https://doi.org/10.13107/bbj.2022.v03i02.043

(Abstract Text HTML)      (Download PDF)


Application of Intra Operative Ultrasound in Spine Surgery

Volume 3 | Issue 2 | October 2022-March 2023 | page: 51-54 | Rakeshkumar C. Luhana, Jinil N. Doshi

DOI: https://doi.org/10.13107/bbj.2022.v03i02.041


Authors: Rakeshkumar C. Luhana [1], Jinil N. Doshi [1]

[1] Department of Spine Surgery, Venus Superspeciality Hospital, Vadodara, Gujarat, India.

Address of Correspondence

Dr. Rakeshkumar Luhana,
Department of Spine Surgery, Venus Superspeciality Hospital, Vadodara, Gujarat, India.
E-mail:rcluhana@gmail.com


Abstract


Objective: Intraoperative ultrasound is a real time imaging modality. Though was introduced in 1980s, not widely used. It is applicable for Intradural lesions as well as pathology ventral to cord, while doing posterior approach and helps us to make surgery safer. Our objective is to share technique as well as our experience of intra operative ultrasound by sharing illustrative cases.
Method: our Surgical cases were reviewed and identified cases where we used intraoperative ultrasound. Illustrative cases were selected and compiled.
Results: This article describes technique of intra operative ultrasound and several illustrative cases were demonstrated.
Conclusion: Intraoperative ultrasound is a real time imaging tool and can be used for various indications especially for intradural lesions and addressing ventral pathology from posterior routes.
Keywords: Intra operative ultrasound, Real time imaging, Intra operative adjunct


References


1. Dohrmann GJ, Rubin JM. Intraoperative ultrasound imaging of the spinal cord: syringomyelia, cysts, and tumors—a preliminary report. Surg Neurol. 1982;18:395–399.
2. Braun IF, Raghavendra BN, Kricheff II. Spinal cord imaging using real-time high-resolution ultrasound. Radiology. 1983;147:459–465.
3. Knake JE, Gabrielsen TO, Chandler WF, Latack JT, Gebarski SS, Yang PJ. Real-time sonography during spinal surgery. Radiology. 1984;151:461–465.
4. Rubin JM, Dohrmann GJ. The spine and spinal cord during neurosurgical operations: real-time ultrasonography. Radiology. 1985;155:197–200.
5. Montalvo BM, Quencer RM. Intraoperative sonography in spinal surgery: current state of the art. Neuroradiology. 1986;28:551–590.
6. Pasto ME, Rifkin MD, Rubenstein JB, Northrup BE, Cotler JM, Goldberg BB. Real-time ultrasonography of the spinal cord: intraoperative and postoperative imaging. Neuroradiology. 1984;26:183–187.
7. Quencer RM, Montalvo BM, Eismont FJ, Green BA. Intraoperative spinal sonography in thoracic and lumbar fractures: evaluation of Harrington rod instrumentation. AJR Am J Roentgenol. 1985;145:343–349.
8. Quencer RM, Montalvo BM, Green BA, Eismont FJ. Intraoperative spinal sonography of soft-tissue masses of the spinal cord and spinal canal. AJR Am J Roentgenol. 1984;143:1307–1315.
9. Quencer RM, Morse BM, Green BA, Eismont FJ, Brost P. Intraoperative spinal sonography: adjunct to metrizamide CT in the assessment and surgical decompression of posttraumatic spinal cord cysts. AJR Am J Roentgenol. 1984;142:593–601.
10. Rubin JM, Dohrmann GJ. Work in progress: intraoperative ultrasonography of the spine. Radiology. 1983;146:173–175.
11. McGahan JP, Benson D, Chehrazi B, Walter JP, Wagner FC., Jr Intraoperative sonographic monitoring of reduction of thoracolumbar burst fractures. AJR Am J Roentgenol. 1985;145:1229–1232.
12. Sosna J, Barth MM, Kruskal JB, Kane RA. Intraoperative sonography for neurosurgery. J Ultrasound Med. 2005;24:1671–1682.
13. Toktas ZO, Sahin S, Koban O, Sorar M, Konya D. Is intraoperative ultrasound required in cervical spinal tumors? A prospective study. Turk Neurosurg. 2013;23:600–606.
14. Harel R, Knoller N. Intraoperative spine ultrasound: application and benefits. Eur Spine J. 2016;25:865–869..
15. Prada F, Vetrano IG, Filippini A, et al. Intraoperative ultrasound in spinal tumor surgery. J Ultrasound. 2014;17:195–202.
16. Zhou H, Miller D, Schulte DM, et al. Intraoperative ultrasound assistance in treatment of intradural spinal tumours. Clin Neurol Neurosurg. 2011;113:531–537.
17. Bozinov O, Burkhardt JK, Woernle CM, et al. Intra-operative high frequency ultrasound improves surgery of intramedullary cavernous malformations. Neurosurg Rev. 2012;35:269–275.
18. Sciubba DM, Liang D, Kothbauer KF, Noggle JC, Jallo GI. The evolution of intramedullary spinal cord tumor surgery. Neurosurgery. 2009;65:84–91.
19. Regelsberger J, Fritzsche E, Langer N, Westphal M. Intraoperative sonography of intra-and extramedullary tumors. Ultrasound Med Biol. 2005;31:593–598.
20. Iacopino DG, Conti A, Giusa M, Cardali S, Tomasello F. Assistance of intraoperative microvascular doppler in the surgical obliteration of spinal dural arteriovenous fistula: cases description and technical considerations. Acta Neurochir. 2003;145:133–137.
21. Friedman JA, Wetjen NM, Atkinson JL. Utility of intraoperative ultrasound for tumors of the Cauda equina. Spine (Phila Pa 1976). 2003;28:288–290.
24. Tekula F, Pritz MB, Kopecky K, Willing SJ. Usefulness of color Doppler ultrasound in the management of a spinal arteriovenous fistula. Surg Neurol. 2001;56:304–307.
25. Lunardi P, Acqui M, Ferrante L, Fortuna A. The role of intraoperative ultrasound imaging in the surgical removal of intramedullary cavernous angiomas. Neurosurgery. 1994;34:520–523.
26. Matsuzaki H, Tokuhashi Y, Wakabayashi K, Toriyama S. Clinical values of intraoperative ultrasonography for spinal tumors. Spine (Phila Pa 1976). 1992;17:1392–1399.
27. Kawakami N, Mimatsu K, Kato F. Intraoperative sonography of intramedullary spinal cord tumours. Neuroradiology. 1992;34:436–439.
28. Epstein FJ, Farmer JP, Schneider SJ. Intraoperative ultrasonography: an important surgical adjunct for intramedullary tumors. J Neurosurg. 1991;74:729–733.
29. Platt JF, Rubin JM, Chandler WF, Bowerman RA, DiPietro MA. Intraoperative spinal sonography in the evaluation of intramedullary tumors. J Ultrasound Med. 1988;7:317–325.
30. Harrop JS, Ganju A, Groff M, Bilsky M. Primary intramedullary tumors of the spinal cord. Spine (Phila Pa 1976). 2009;34(22 suppl):S69–S77.
31. Nishimura Y, Thani NB, Tochigi S, Ahn H, Ginsberg HJ. Thoracic discectomy by posterior pedicle-sparing, transfacet approach with real-time intraoperative ultrasonography: clinical article. J Neurosurg Spine. 2014;21:568–576.
32. Seichi A, Chikuda H, Kimura A, et al. Intraoperative ultrasonographic evaluation of posterior decompression via laminoplasty in patients with cervical ossification of the posterior longitudinal ligament: correlation with 2-year follow-up results. J Neurosurg Spine. 2010;13:47–51.
33. Aoyama T, Hida K, Akino M, Yano S, Iwasaki Y. Detection of residual disc hernia material and confirmation of nerve root decompression at lumbar disc herniation surgery by intraoperative ultrasound. Ultrasound Med Biol. 2009;35:920–927.
34. Tokuhashi Y, Matsuzaki H, Oda H, Uei H. Effectiveness of posterior decompression for patients with ossification of the posterior longitudinal ligament in the thoracic spine: usefulness of the ossification-kyphosis angle on MRI. Spine (Phila Pa 1976). 2006;31:E26–E30.
35. Mueller LA, Degreif J, Schmidt R, et al. Ultrasound-guided spinal fracture repositioning, ligamentotaxis, and remodeling after thoracolumbar burst fractures. Spine (Phila Pa 1976). 2006;31:E739–E746.
36. Matsuyama Y, Kawakami N, Yanase M, et al. Cervical myelopathy due to OPLL: clinical evaluation by MRI and intraoperative spinal sonography. J Spinal Disord Tech. 2004;17:401–404.
37. Lazennec JY, Saillant G, Hansen S, Ramare S. Intraoperative ultrasonography evaluation of posterior vertebral wall displacement in thoracolumbar fractures. Neurol Med Chir (Tokyo). 1999;39:8–14.
38. Blumenkopf B, Daniels T. Intraoperative ultrasonography (IOUS) in thoracolumbar fractures. J Spinal Disord. 1988;1:86–93.
39. Randel S, Gooding GA, Dillon WP. Sonography of intraoperative spinal arteriovenous malformations. J Ultrasound Med. 1987;6:539–544.
40. Viren s, Muhammad A, Yuri a et al. Use of intraoperative ultrasound in spine surgery. Global Spine Journal.2017;7(7);648-656
41. Mario G, Nikolaos S, Allan R et al. Intraoperative ultrasound in Spine surgery: history, current applications, future developments. Quant Imaging Med Surg 2018;8(3):261-267
42. Ahmed A, Hussam A, Alaa A et al. The utility of ultrasound for surgical spinal decompression. Med Ultrason 2015;17(2): 211-218


How to Cite this Article: Luhana R, Doshi J |  Application of Intra Operative Ultrasound in Spine Surgery | Back Bone: The Spine Journal | October 2022-March 2023; 3(2): 51-54. https://doi.org/10.13107/bbj.2022.v03i02.041

(Abstract Text HTML)      (Download PDF)


.